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Background Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. Aims To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO) topical gel versus placebo on Demodex density (Dd) and clinical manifestation using standard skin surface biopsy (SSSB) in rosacea patients. Patient/Methods In this double‐blind, randomized clinical trial, 47 papulopustular rosacea patients were enrolled, with 35 patients finishing the 12 weeks of treatment. Each patient used permethrin 2.5% with TTO on one side of the face and a placebo on the other, twice daily for 12 weeks. SSSB, photography and clinical rosacea scores according to National Rosacea Society, as well as adverse drug reaction (ADRs) were reported at the baseline, 2nd, 5th, 8th, and 12th weeks. Results A total of 47 patients were enrolled with papulopustular rosacea, and 35 patients finished the study. The effects of permethrin 2.5% with TTO gel on mite density were significant at week 5, 8, 12 (P value = .001). Clinical features and global assessments showed papules, pustules and nontransient erythema had improvement in drug group after 12 weeks (P values <.05). The improvement of burning and stinging and dry appearance was greater than the placebo gel (P value <.05). Itching in placebo group was significantly more than other group (P value = .002). Conclusion Administration of permethrin 2.5% with TTO gel demonstrated good efficacy and safety in rosacea. This topical gel inhibited the inflammatory effects of rosacea and reduced Demodex mite.

Metal-organic frameworks (MOFs) are organic-inorganic hybrid crystalline porous with high specific surface areas that have revolutionized materials science and adsorbent development. The research aims to investigate and develop QSPR (quantitative...

The aim of this survey was to assess the public health risk from certain brands of lipsticks products sold at local markets in Tehran. To investigate claims that some brands of cosmetic products sold at Iranian stores were non-complaint with the cosmetic products Group Standard 2006 under the Hazardous Substances, we focused only on the presence of total and Leachable Lead and Cadmium in randomly selected lipsticks. 120 samples of 19 brands of lipsticks made from different countries were randomly purchased for analysis but a single brand may contain several colors which have been analyzed separately. The samples were analyzed according to standardized international protocols by wet digestion method, by a Flame Emission Spectrophotometer. The highest concentration of lead and Cadmium was detected in Chinese lipsticks .The mean content of lead in 95.91% 0f Chinese lipsticks are much higher than 20 µg/g and all of the Iranian lipsticks are lower than 10 µg/g. There is significant difference in the levels of Lead in the entire four main color group analyzed. The pink color has highest concentration of lead, while violet color has the lowest Lead content and the brown and orange color have the highest and lowest concentration of cadmium respectively. The safety assessment of cosmetic products such as lipsticks is a complex issue that is not only affected by scientific questions, but also by the responsible regulatory organizers as well as consumers, health ministry and governmental organizers, there is an urgent to halt importing unsafe cosmetics.