Introduction: Irrigating solutions have a key role in providing a successful root canal treatment in primary teeth. Silver diamine fluoride (SDF) is a clear liquid that has an antibacterial potential and was found to be effective against E. faecalis bacteria, which is found in resistant non healing endodontic cases. Materials and Methods:Sixty non-vital primary molars were included in this randomized clinical trial. Each child had a molar randomly assigned to Group A and the other molar to Group B. In Group A, 30 primary molars were irrigated with 2.5% NaOCl and 17% EDTA solution as a positive control group. In Group B, 3.8% SDF was used as an irrigating solution for 30 primary molars along with the 2.5 % NaOCl and 17%EDTA. The teeth were clinically evaluated each follow up visit for the following clinical features: spontaneous pain, sensitivity to percussion, changes of the muco-buccal folds.Results: At 3 months and 6 months periods, Group A showed statistically significant greater number of cases showing spontaneous pain. After 6 months; Group A showed a statistically significant increase in sensitivity to percussion compared to Group B (P-value = 0.035, effect size = 0.385). After 6 months; Group A showed a statistically significant changes in the mucco-buccal fold compared to Group B (P-value = 0.035, Effect size = 0.385). Conclusions:• SDF 3.8% can be used successfully as an irrigating solution.• Adding SDF 3.8% in the irrigation regimen will improve the disinfection of the root canals and ultimately the treatment outcome.