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The levels of Cr (2.49±0.89 ppm), Mn (5.08 ± 1.60 ppm), Ni (1.81±0.95 ppm) and Pb (4.43 ± 3.12 ppm) were measured in dessicated liver from 44 cases of sudden traumatic death considered as representative of the general population in our area, after ruling out the presence of any underlying disease. Atomic absorption spectrophotometry and electrothermal atomitazion was carried out after hot, acid digestion, of the dessicated samples. After cancelling the influence of age and cause of death, a significant, positive correlation between Cr/Mn (P = 0.0009; R = 0.493) and Cr/Ni ( P = 0.0245; R = 0.347) levels was found.

Lewis Acid Stereocontrolled Addition of a Silyl Ketene Acetal to 2,3-Di-O-isopropylidene-D-glyceraldehyde Nitrones.Synthesis of L-Isoxazolidinyl Nucleosides.-Under optimized conditions, the BF 3etherate promoted addition of the silyl ketene acetal (II) to a D-glyceraldehyde derived nitrone (I) gives the isoxazolidinone (III) in high yield and stereoselectivity. The anti product is readily converted to key intermediates (VIII) and (IX) of L-isoxazolidinyl nucleosides such as (X) and (XI). -(MERINO, PEDRO; DEL ALAMO, EVA M.; BONA, MAITE; FRANCO, SANTIAGO; MERCHAN, FRANCISCO L.; TEJERO, TOMAS; VIECELI, ODILE; Tetrahedron Lett. 41 (2000) 48, 9239-9243; Dep. Quim. Org., ICMA, Fac. Cienc., Univ. Zaragoza,