BackgroundDifferences in the incidence and outcome of breast cancer among Hispanic women compared with white women are well documented and are likely explained by ethnic differences in genetic composition, lifestyle, or environmental exposures.Methodolgy/Principal FindingsA population-based study was conducted in Galicia, Spain. A total of 510 women diagnosed with operable invasive breast cancer between 1997 and 2010 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics were collected. The different breast cancer tumor subtypes were compared on their clinico-pathological characteristics and risk factor profiles, particularly reproductive variables and breastfeeding. Among the 501 breast cancer patients (with known ER and PR receptors), 85% were ER+/PR+ and 15% were ER-&PR-. Among the 405 breast cancer with known ER, PR and HER2 status, 71% were ER+/PR+/HER2- (luminal A), 14% were ER+/PR+/HER2+ (luminal B), 10% were ER−/PR−/HER2- (triple negative breast cancer, TNBC), and 5% were ER−/PR−/HER2+ (non-luminal). A lifetime breastfeeding period equal to or longer than 7 months was less frequent in case patients with TNBC (OR = 0.25, 95% CI = 0.08–0.68) compared to luminal A breast cancers. Both a low (2 or fewer pregnancies) and a high (3–4 pregnancies) number of pregnancies combined with a long breastfeeding period were associated with reduced odds of TNBC compared with luminal A breast cancer, although the association seemed to be slightly more pronounced among women with a low number of pregnancies (OR = 0.09, 95% CI = 0.005–0.54).Conclusions/SignificanceIn case-case analyses with the luminal A cases as the reference group, we observed a lower proportion of TNBC among women who breastfed 7 or more months. The combination of longer breastfeeding duration and lower parity seemed to further reduce the odds of having a TNBC compared to a luminal A breast cancer.

BackgroundBreast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.Materials and MethodsA population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.ResultsAmong the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ER−&PR−. Women with a family history of breast cancer were more likely to have ER−&PR− tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91–2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34–5.81).ConclusionsAn increased proportion of ER−&PR− breast cancer was observed among younger Spanish women with a family history of the disease.

Although alcohol intake is an established risk factor for overall breast cancer, few studies have looked at the relationship between alcohol use and breast cancer risk by the four major subtypes of breast cancer and very few data exist in the alcohol-breast cancer relationship in Spanish women. A population-based case-control study was conducted in Galicia, Spain. A total of 1766 women diagnosed with invasive breast cancer between 1997 and 2014 and 833 controls participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics were collected. We examined the alcohol-breast cancer association according to the major breast cancer subtypes [hormone-receptor-positive, HER2-negative (luminal A); hormone-receptor-positive, HER2-positive (luminal B); hormone-receptor-negative, HER2-negative (TNBC); and hormone-receptor-negative, HER2-positive (HER2 overexpressing)] as well as grade and morphology in Spanish women. With the exception of HER2 overexpressing, the risk of all subtypes of breast cancer significantly increased with increasing alcohol intake. The association was similar for hormonal receptor positive breast cancer, i.e., luminal A and luminal B breast cancer (odds ratio, OR 2.16, 95 % confidence interval, CI 1.55–3.02; and OR 1.98, 95 % CI 1.11–3.53, respectively), and for TNBC (TNBC: OR 1.93, 95 % CI 1.07–3.47). The alcohol-breast cancer association was slightly more pronounced among lobular breast cancer (OR 2.76, 95 % CI 1.62–4.69) than among ductal type breast cancers (OR 2.21, 95 % CI 1.61–3.03). In addition, significant associations were shown for all grades, I, II and III breast cancer (OR 1.98, 95 % CI 1.26–3.10; OR 2.34, 95 % CI 1.66–3.31; and OR 2.16, 95 % CI 1.44–3.25 for Grades I, II and III, respectively). To our knowledge, this is the first study to examine the association of breast cancer subtypes and alcohol intake in Spanish women. Our findings indicate that breast cancer risk increased with increasing alcohol intakes for three out of the four major subtypes of breast cancer. The association was similar for hormonal receptor positive breast cancer, i.e., luminal A and luminal B breast cancer, and for TNBC. The association seemed to be slightly more pronounced for lobular than ductal breast cancers. No differences were detected by grade.

Background and Purpose of Study: our study aims to determine whether the use of Lipofilling (LPF) after conservative surgery (CS) of invasive breast cancer (BC) is a possible risk factor in the local recurrence of this tumor. As secondary objectives, we will assess patient satisfaction after LPF and the percentage of patients with post-operative asymmetries.Material and Methods: we carried out a retrospective, case-control study. We selected patients who, between 2010 and 2014, had undergone CS of Invasive BC, and were subsequently treated with LPF (using the Coleman technique) and controls had undergone CS of BC without later use of LPF. The minimum follow-up time was 5 years. Results:No local recurrence was observed in the controls, but in the cases, 4 local recurrences were observed. This implies an incidence of 20 % in CS after LPF, a statistically significant difference with a p-value of 0.0036. The influence on recurrence of tumor size variables, vascular involvement, duration of hormone therapy and use of chemotherapy has been analyzed, without finding any statistically significant differences between cases and controls. No influence has been observed on the time elapsed from the date when CS and the first LPF and the volume of fat transferred with the risk of local recurrence. Likewise, 50 % of patients are satisfied with LPF reconstruction and 20 % have presented asymmetries later. Conclusion:LPF may be a risk factor in local recurrence of invasive breast cancer after CS.

Background Although alcohol intake is an established risk factor for overall breast cancer, few studies have looked at the relationship between alcohol use and breast cancer risk by subtype of breast cancer. Materials and Methods A population-based study was conducted in Galicia, Spain. A total of 1211 Spanish women diagnosed with operable invasive breast cancer between 1997 and 2010 and 550 controls participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics were collected. The four major breast cancer subtypes [hormone-receptor-positive, HER2-negative (luminal A); hormone-receptor-positive, HER2-positive (luminal B); hormone-receptor-negative, HER2-negative (triple-negative); and hormone-receptor-negative, HER2-positive (HER2 over-expressing)] were compared on their clinico-pathological characteristics and risk factor profiles, particularly alcohol intake and reproductive variables. Results With the exception of Her2 overexpressing, the risk of all subtypes of breast cancer increased with increasing alcohol intake (luminal A: OR=2.32, 95%CI:1.43-3.77; luminal B: OR=2.03, 95%CI 1.01-4.06, and triple negative: OR=2.36, 95%CI 1.11-5.00). The association of alcohol with breast cancer was similar among women who drank wine exclusively and other drinkers. The alcohol-breast cancer association appeared to be more pronounced among lobular breast cancers (OR= 2.70, 95% CI:1.33-5.52) than among ductal type breast cancers (OR= 2.09, 95%CI:1.33-3-01). It has been suggested that the association of alcohol intake with breast cancer may be stronger in women who are current or past users of hormone replacement therapy compared with never users, or among non-ovariectomized compared to ovariectomized women, we found no such differences. Conclusions To our knowledge, no prior study has examined the association of breast cancer with alcohol intake according to breast cancer subtypes and the type of wine consumed in Spanish women. Our findings indicate that breast cancer risk increased with increasing alcohol intakes for three out of the four major subtypes of breast cancer and that the risk was similar in women who drank wine, beer and/or liquor exclusively or in mixture. Citation Format: Manuela Gago-Dominguez, Carmen M. Redondo, Manuel Enguix, Maite Peña Fernandez, Maria Elena Martinez, Victor Munoz, Angel Carracedo, Francisco Gude, Jose Esteban Castelao. Alcohol and breast cancer subtypes in a Spanish cohort. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 139. doi:10.1158/1538-7445.AM2013-139