Concurrent chemoradiotherapy (CHRT) remains the therapeutic standard for locally advanced inoperable non-small-cell lung cancer (NSCLC). The median overall survival (OS) with this approach is in

BackgroundThe aim of this project was to collect real-world evidence and describe treatment patterns for stage III non-small cell lung cancer in Central and Eastern Europe. Based on real-world evidence, an expert opinion was developed, and the unmet needs and quality indicators were identified.Patients and methodsA systematic literature search and a multidisciplinary expert panel of 10 physicians from 7 countries used a modified Delphi process to identify quality indicators and unmet needs in patients with stage III non-small cell lung cancer. The profound questionnaire was used to characterize treatment patterns used for stage III non-small cell lung cancer, and a systematic review identified patterns in Central and Eastern Europe. The first questionnaire was completed by a group of medical oncologists, radiation oncologists and pneumologists. The panel of experts attended an in-person meeting to review the results of the questionnaire and to process a second round Delphi. An additional survey was then compiled and completed by the panel.ResultsA complete consensus was reached by the panel of experts on a set of evidence-based clinical recommendations. The experience-based questionnaire generated a highly variable map of treatment patterns within the region. A list of unmet needs and barriers to quality care were developed with near-unanimous consent of the panel of experts.ConclusionsThe current landscape of diagnostic and therapeutic approaches in Central and Eastern European countries is highly variable. We identified several significant barriers, mainly related to the availability of diagnostic and imaging methods and low rates of chemoradiotherapy with curative intention as initial treatment for unresectable stage III NSCLC.

Przerzuty do tarczycy i trzustki występują rzadko. Względnie częstym ogniskiem pierwotnym jest rak nerki. Brak jest jasnych wytycznych dotyczących leczenia chirurgicznego zmian przerzutowych w tych lokalizacjach. W pracy przedstawiono rzadki przypadek równoczesnych przerzutów do tarczycy i trzustki wiele lat po leczeniu operacyjnym z powodu raka nerki. Concomitant renal cancer metastases to the pancreas and thyroid gland: case report and literature review Metastases to the thyroid gland or pancreas are rare and renal cancer is one of the most common primary tumours. There is no consensus regarding surgical treatment of metastases in these sites. We present a rare case of concomitant pancreatic and thyroid metastases in a renal cancer patient many years after surgery.

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Laryngeal cancer occurs rarely in adolescents and young people. Castleman’s disease is a rare lymphoproliferative disorder of uncertain etiopathogenesis and heterogeneous clinicopathological forms. Involved lymph nodes and extranodal lesions in the course of Castleman’s disease may mimic malignant involvement. We report a case of an 18-year-old woman with T2N0M0 laryngeal glottis cancer treated with definitive radiotherapy. During the irradiation, the patient underwent an excision of incidentally discovered left-sided enlarged cervical lymph nodes located outside the irradiated area. Coincidental hyaline vascular type of Castleman’s disease was diagnosed. During six-year follow-up she has been free of cancer relapse and Castleman’s disease symptoms.