Back ground: Nursing care for mechanically ventilated patients is an integral part of changing the rate of ventilator associated infections in the intensive care units, also the time of depending on mechanical ventilator. Aim: This study aimed to assess nursing performance toward infection control measures for mechanically ventilated patients. Design: A descriptive explorative design was utilized for the conduction of this study. Setting: this study was conducted in intensive care units at emergency hospital affiliated to Ain Shams University. Study subject: A purposive sample of 60 nurses who provide direct care for mechanically ventilated patients were included. Three tools were used for data collection Tools: (I) -Self -administration questionnaire, (II) nurses' practice observational checklist, (Ш) nurses' attitude questionnaire. Results: revealed that, 47% of studied nurses had satisfactory knowledge, while 58.3% of them had unsatisfactory level of practices. Also, 65% of the studied nurses had positive attitude toward infection control measures for mechanically ventilated patients. Recommendations: further researches are recommended to evaluate nurse's performance regarding infection control measures for mechanically ventilated patients.