Ionized calcium represents the portion of total calcium and has biologically active; this study has been debated whether the calcium homeostasis status in correlated with anti-Mullerian hormone level how does influence on the reproductive ability in some pre-menopausal women. Eighty volunteer women non-smoking (20-35) years enrolled in this study,some of them (50 women) with primary infertility considered as study group,while the other 30 volunteer parous women considered as control group,non-fasting blood samples were taken from subjects during October 2015 till may 2016. ELISA kit was used to assay the serum level of anti-Mullerian and parathyroid hormone,whereas colorimetric method was used to determine serum total calcium,albumin and inorganic phosphorus,while ionized calcium is calculated by special equation depending on the total calcium and albumin level. Independent T-test analysis was used to determine any significant difference for investigated parameters between control and study group,linear regression analyses were in addition used to explore the association between ionized calcium and anti-Mullerian hormone (AMH) level in both control and infertile groups.infertile group have significantly p<0.001 lower mean serum ionized calcium level (4.31±0.61mg/dl) than in the control group (5.57±0.45mg/dl) accompanied by significantly increase in parathyroid hormone level (94.2±32.2ng/dl) in study groupin comparison with control group where they showed (92.1±22.2 ng/dl) mean concentration,in addition those infertile women had higher significantly (p<0.05) albumin level compared with those in control group,in addition to that,mean serum phosphorus level showed a significantly higher (p<0.01) in study group compared with its level in the control group,however infertile women revealed significantly decrease mean level in anti-Mullerian hormone (2.59±1.38ng/dl)compared with the hormone level in the control group (4.33±1.00ng/dl).As such results of linear regression analyses revealed a significant positive correlation between ionized calcium concentration and AMH level (r=0.58,p=0.000,n=40) in control group, as well,there was a significant strong positive correlation was seen between serum ionized calcium and AMH level for the infertile group (r=0.70,p=0.000,n=50).any physiological process including reproductive ability may need in one way or another to calcium metal. So,it's necessary maintain the concentration of blood calcium within stable normal range to ensure the work of most biological system properly including reproductive capacity and any disturbance in calcium homeostasis may have been altered the ovarian reserve which may in turn,reduce reproductive capacity.
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