No abstract

There is a shortage of pediatric liver allografts available for transplantation, and at the same time, there are over 100 allografts discarded each year. In 2006, the DRI was developed using donor factors and cold ischemia time to predict liver graft failure. 1 However, the DRI has little clinical relevance due to its poor predictive capacity. [2][3][4][5] Because of this poor predictive capacity, marginal allografts are accepted based on the surgeon's subjective assessment of the donor allograft at the time of donation. This assessment, coupled with liver biopsy results, has often resulted in allografts being accepted despite adverse laboratory values and demographic characteristics. 5,6 Similarly, allografts that might have otherwise been successfully transplanted were likely discarded.

Background: Liver Transplantation has advanced over the past 3 decades, with 1-year survival rates improving 25%. Survival rates for those transplanted has increased to remarkable levels, but survival from the time of listing may not be as revolutionary.Methods: Kaplan-Meier with log-rank test as well as Cox regression analysis was used to retrospectively analyze 211 610 adults listed for LT and 116 299 adult transplant recipients from 1987 to 2016. Our primary endpoints were survival from time of listing to waitlist death or posttransplant death.Results: One-year survival following LT improved dramatically (68% in 1987LT improved dramatically (68% in -1988

No abstract

No abstract