The pharmacokinetic parameters of colistin were comparable to those reported in previous studies in critically ill patients. However, the recommended dose may be inadequate to maintain the C(max)/MIC ratio to an optimal level-at least in patients infected with Pseudomonas spp. The dose recommendation should be based only on creatinine clearance and not body weight.

Perioperative pneumothorax is a potentially dangerous and rare complication during general anaesthesia. Hereby the authors report a case of 25-year-old female, who was posted for a dental procedure, and developed spontaneous pneumothorax under general anaesthesia. The patient had no co-morbidities or risk factors during the perioperative period and classified as American Society of Anaesthesiologist’s (ASA) class I. She was planned under general anaesthesia with an orotracheal intubation with controlled positive pressure ventilation. At the end of the surgery, she developed significant respiratory changes which rose the suspicion of pneumothorax and later, it was confirmed radiologically. This early suspicion and early intervention by tube thoracostomy in Postanaesthesia Care Unit (PACU) stabilised the patient and resolved eventually. Early recognition and appropriate intervention can mitigate the perioperative outcome and reduce morbidity. Positive pressure ventilation, Positive End Expiratory Pressure (PEEP) and airway handling being the major predisposing factors for the development of pneumothorax. This further reiterates the need for keen perioperative vigilance for early recognition and appropriate management. Although rare, pneumothorax should be considered as differential diagnosis in crisis scenarios like tight bag.

Introduction: The aim of the study was to observe haemodynamic changes during induction of patients undergoing CABG with Propofol and Pentothal. It was also intended to see if fixed dose combination of premedication with midazolam and fentanyl helps to reduce dose requirement of induction agents. Material Methods: 60 ASA grade II patients posted for elective Coronary Artery Bypass Surgery (CABG) were divided into two groups. Group I (propofol group) and group II (pentothal Group). All patients received premedication as Inj.Midazolam 0.03 mg/kg and Inj.Fentanyl 4 µg/kg. With computer generated randomization patient was allotted to either propofol or Pentothal group. End point of induction taken as loss of eyelash reflex or apnoea whichever appears first. Hemodynamic parameters were recorded from baseline till 7 minutes post intubation. Results: In both the groups SBP, DPB, MAP, HR and RPP were found to be comparable. Both the drugs showed stable hemodynamic at various levels of observations. The mean dose required for induction was found to be 1.7 mg/kg with propofol and 1.07 mg/kg with Pentothal. Conclusion: Both propofol and Pentothal are equally able to provide required stability even when standard doses of benzodiazepines and opioids are used in much lower doses than mentioned in literature.