BACKGROUND To improve patient care and safety in relation to the use of medicines and providing early warnings regarding ADR and the risk groups associated with its development, which might affect the success of the programme. It will thus support the safe and more effective use of medicine. MATERIALS AND METHODS A prospective study done from Indoor Patient Department (IPD) Medicine and IPD Tuberculosis and Chest (including DOTS and DOTS Plus Centre) in Sri Krishna Medical College and Hospital (SKMCH), Muzaffarpur, Bihar, from April 2015 to June 2016. Total of 500 patients included in the study and reviewed for at least first 2 months of initiation of treatment. Naranjo adverse drug reaction probability scale and Hartwig's severity assessment scale were utilised for determination of probability and severity of ADR, respectively. RESULTS 500 patients included in study were analysed. ADR was found in 60 patients (incidence of ADR12%), mostly presented within first 30 days of initiation of treatment and mostly it is due to multidrug treatment and the most common drugs responsible were isoniazid, then rifampicin and pyrazinamide, which were more common in female patients (36) as compared to male patients (24), most cases were mild and had probable relationship. Most cases recovered spontaneously while some required symptomatic and very few required specific treatment. The most common ADR noted was hepatobiliary (increased in liver enzyme (54.69%)).95% of cases showing ADR were between 31.2 to 56.8 years of age and between 26.47 to 76.87 kg weight. CONCLUSION In our study, incidences of ADR of antitubercular drug was around 12% and hepatobiliary manifestations in the form of raised liver enzymes is the most common manifestation. The most common drug responsible is isoniazid. ADRs are more common in females and in rural population with mean age 44 years and mean weight of 51.67 kg and mostly noticed within 30 days of initiation of treatment. Most of the ADRs are minor in severity and resolve spontaneously.

BACKGROUND The aim of the study is to search out the incidence of complications of measles immunisation in malnourished children. MATERIALS AND METHODS Sample selected from OPD Paediatric Department, PMCH, Patna, over a period of 1 st April, 2006, to 31 st March, 2007, during my posting period. Participants-Simple randomly selected 400 children (8-24 months) of Patna, immunised against measles. Statistical Analysis-Proportion, percentage, incidence rate, Chi-square test were performed. Design-Longitudinal study. RESULTS Total 400 children were followed up for one calendar year. There was no statistical association between age, sex and complications developed in children. Out of 400 children complications developed in 25 children among these malnutrition was the commonest risk factor (80%) and statistically significant (P<0.05) followed by other associated factors. CONCLUSION Higher incidence of complications in malnourished vaccines illustrates the government and other healthcare providers to strengthen the surveillance for vaccine-associated complications.

BACKGROUND Tuberculosis is an infectious disease which is prevalent worldwide, especially in developing nations and shows difficulty in elimination of disease due to resistant strains. So, there is a need of better and more effective control programs for tuberculosis patients and periodical survey for drug resistance patterns to formulate better treatment regimen and to make national tuberculosis program more strong and effective. MATERIALS AND METHODS A Prospective study has been conducted on 700 newly detected smear-positive TB patients who initiate receiving anti Tubercular drugs and had no history of previous anti tuberculosis treatment from April 2015 to April 2016. Sputum for AFB was done to detect the infection and Gene expert method and culture & sensitivity method done for detection of drug resistance of Isoniazid, Rifampicin, Ethambutol, Pyrazinamide & Streptomycin. RESULTS Out of 700 smear positive patients 628 patients were found culture positive and of them 560 were sensitive to all drugs, 48 patients shown resistance (7.8947%). Most common drug showing resistance is Rifampicin (3.94%) then Isoniazid (2.3%). Resistant pattern more for females, illiterate persons, married persons, rural patients with mean age 40.1 years, median age 38.5 years, S.D. 18.7, p-value 0.024112215. CONCLUSION In our study more resistant pattern seen for Rifampicin, which is more in married, illiterates, rural, female patients. So, a periodical assessment of the prevalence of drug resistance pattern is very essential not only to know the effectiveness of the program but also to plan suitable regimens in areas of high prevalence.