An inflammatory liposarcoma is a rare variant of a well-differentiated liposarcoma. A case of a giant variety of an inflammatory well-differentiated liposarcoma is being reported. CT scan revealed a large abdomino-pelvic mass which had displaced the gut loops to left and posteriorly and urinary bladder and uterus to right. FNAC yielded mature adipocytes with no evidence of atypical cells. The large bossilated and irregular fibro-fatty mass which weighed 23 kg was excised. Microscopy revealed mature adipocytes with foci of fibrosis and abundant inflammatory cell infiltrates of eosinophils, lymphocytes, plasma cells and few neutrophils, along with few atypical cells. Only a few cases of a giant inflammatory variant of a well-differentiated liposarcoma have been reported in the world literature and this is first of its kind from the Indian sub-continent. A rare giant variant of a inflammatory well-differentiated liposarcoma with abundant eosinophils is being reported here, along with review of literature.