BACKGROUNDLaboratory Risk Indicator for Necrotizing Fasciitis (LRINEC score) is a simple laboratory tool used to distinguish between Necrotizing Soft-Tissue Infections (NSTI) and other soft-tissue infections. A LRINEC score of ≥6 is considered as denoting a high risk of necrotizing fasciitis. A very high LRINEC score might also be associated with mortality and other outcomes of patients with NSTI.

BACKGROUND Recurrent aphthous stomatitis (RAS) is the most common ulcerative disorder of oral mucosa. The etiopathogenesis of RAS is multifactorial; however, recent studies have proposed Helicobacter pylori (H. pylori) as one of the causative factors. Helicobacter pylori is a known pathogen causing upper gastrointestinal symptoms and gastric ulcers. Oral cavity is one of the extra gastric reservoirs and a causative factor for reinfection which further requires eradication therapy. The aim of this systematic review was to retrieve clinical studies investigating the effect on the clinical course of recurrent aphthous stomatitis through gastric Helicobacter pylori eradication. METHODS Literature was searched in electronic search engines from 1997 to 2017. The identified titles/abstracts were independently screened according to the set criteria for selection of abstracts. 6 full text articles were selected and assessed for eligibility. RESULTS All the studies evaluated the subjects with recurrent aphthous stomatitis for the Helicobacter pylori and the positive ones were given H. pylori eradication therapy and were followed up for certain period of time for the recurrence rate, amelioration time, number of lesions, frequency and intensity of the symptoms. Subjects who underwent H. pylori eradication therapy, decrease in the symptoms of recurrent aphthous stomatitis was noted. CONCLUSIONS This systematic review indicates that eradication of H. pylori can be effective in the management of recurrent aphthous stomatitis.