Summary
Understanding patterns of demand is fundamental for fleet management of bike sharing systems. We analyse data from the Divvy system of the city of Chicago. We show that the demand for bicycles can be modelled as a multivariate temporal point process, with each dimension corresponding to a bike station in the network. The availability of daily replications of the process enables non‐parametric estimation of the intensity functions, even for stations with low daily counts, and straightforward estimation of pairwise correlations between stations. These correlations are then used for clustering, revealing different patterns of bike usage.
IMPORTANCE Reduced-intensity conditioning and nonmyeloablative conditioning (RIC-NMAC) regimens are frequently used in allogeneic hematopoietic cell transplant (HCT) for non-Hodgkin lymphoma. However, the optimal RIC-NMAC regimen in allogeneic HCT for non-Hodgkin lymphoma is not known.OBJECTIVE To investigate whether RIC-NMAC regimens at a higher end of the intensity spectrum are associated with increased nonrelapse mortality and lower overall survival compared with RIC-NMAC regimens at the lower end of the intensity spectrum in patients with non-Hodgkin lymphoma undergoing allogeneic HCT.
Reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (allo-HCT) is a curative option for select relapsed/refractory Hodgkin lymphoma (HL) patients, however there is sparse data to support superiority of any particular conditioning regimen. We analyzed 492 adult patients undergoing HLA-matched sibling or unrelated donor allo-HCT for HL between 2008-2016, utilizing RIC with either fludarabine/busulfan (Flu/Bu), fludarabine/melphalan (Flu/Mel140) or fludarabine/cyclophosphamide (Flu/Cy). Multivariable regression analysis was performed using a significance level of <0.01. There were no significant differences between regimens in risk for non-relapse mortality (NRM) (P=0.54), relapse/progression (P=0.02) or progression-free survival (PFS) (P=0.14). Flu/Cy conditioning
Soft palate palsy with or without pharyngeal or laryngeal paralysis or facial palsy has been described in the literature fewer than 40 times. Of these cases, isolated unilateral soft palate palsy (occurring without any other neurologic manifestation) has been rare. Most cases of isolated soft palate palsy were termed idiopathic in the past. In a few cases, a concomitant viral infection such as varicella zoster, herpes simplex, measles, and coxsackie A9 was diagnosed. We describe a case of isolated soft palate palsy, following a pharyngotonsillitis caused by Epstein-Barr virus. This viral infection has been linked in the past with bilateral facial nerve palsy and radial nerve palsy. Our patient recovered spontaneously over a period of 1 month.
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