RESUMO: "Atividade hipolipidemica de Moringa oleifera Lam., Moringaceae, na hiperlipidemia induzida por dieta rica em gordura em ratos albinos." As Unitermos: Moringa oleifera, HMG Co-A reductase, hypolipidemic effect, lipid profile. ABSTRACT:The leaves of Moringa oleifera Lam., Moringaceae, are used by the Indians in their herbal medicine as a hypolipidemic agent in obese patients. Albino Wistar rats were fed with methanolic extract of M. oleifera (150, 300 and 600 mg/kg, p.o.) and simvastatin (4 mg/ kg, p.o.) along with hyperlipidemic diet for 30 days. Moringa oleifera and simvastatin were found to lower the serum cholesterol, triacylglyceride, VLDL, LDL, and atherogenic index, but were found to increase the HDL as compared to the corresponding high fed cholesterol diet group (control). The Moringa oleifera methanolic extract was also investigated for its mechanism of action by estimating HMG CO-A reductase activity. Moringa oleifera was found to increase the excretion of fecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidemic effect.

Two UV-spectrophotometric methods have been developed and validated for simultaneous estimation of valsartan and hydrochlorothiazide in a tablet dosage form. The first method employed solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 249.4 nm and 272.6 nm, max for valsartan and hydrochlorothiazide, respectively. The second method was absorbance ratio method, which involves formation of Q-absorbance equation at 258.4 nm (isoabsorptive point) and also at 272.6 nm ( max of hydrochlorothiazide). The methods were found to be linear between the range of 5-30 g/mL for valsartan and 4-24 g/mL for hydrochlorothiazide using 0.1 N NaOH as solvent. The mean percentage recovery was found to be 100.20% and 100.19% for the simultaneous equation method and 98.56% and 97.96% for the absorbance ratio method, for valsartan and hydrochlorothiazide, respectively, at three different levels of standard additions. The precision (intraday, interday) of methods was found within limits (RSD < 2%). It could be concluded from the results obtained in the present investigation that the two methods for simultaneous estimation of valsartan and hydrochlorothiazide in tablet dosage form are simple, rapid, accurate, precise and economical and can be used, successfully, in the quality control of pharmaceutical formulations and other routine laboratory analysis.

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West Khandesh region of Maharashtra was targeted areas for ethnobotanical survey of medicinal plants used by tribes in the management of liver diseases and simultaneously documentation was made on information. Field of area is densely occupied by various tribes communities like Pawara, Kokani, Bhils, Mavach, Vasave etc. Ethnobotanical survey was carried out after interviewed numbers of different age group traditional healers. It is cleared that, they have huge knowledge of medicinal plants, number of plants, method of preparations and their vernacular names as well as local names, for management of liver diseases. Tribals are strongly believed and have a strong faith on the treatment of medicinal plants by traditional healers. Traditional healers have been diagnosing and treating their patient in number of ways like skin color of patient, voice and tongue condition, herbal medicines are given in different forms to patient. Thirty numbers of plants belong to Rubiaceae, Mimosaceae, Nyctaginaceae, Acanthaceae, Cucurbitaceae and Convolvulaceae families are used by traditional healers in the management of liver disorders.