Background:Eribulin mesylate is a non-taxane microtubule inhibitor which can be used after anthracycline and taxane treatment in patients with metastatic breast cancer (MBC). The purpose of this study was to investigate the efficacy and safety of eribulin monotherapy in heavily pretreated patients with MBC.Methods:In this study, a total of 45 eligible patients with MBC who received eribulin in HCG Cancer Speciality Center from November 2014 to March 2016 were prospectively analyzed. Breslow (generalized Wilcoxon) survival analysis was carried out for progression-free survival and for overall survival. Patients were excluded if they had not taken treatment for 3 cycles and defaulted/expired during the treatment.Results:In this study, median age of patients was 52 years. A total of 27 (60%) patients had estrogen receptor and progesterone receptor (PR) positive primary tumors, whereas HER2 was overexpressed or amplified in 7 (15.6%); a triple negative subtype was recorded in 13 patients (28.9%). Regarding toxicity, 30 patients (66.67%) tolerated treatment well and 3 patients (6.67%) got anemia, 6 patients (13.3%) experienced neutropenia, and 7 (15.62%) patients had neurological toxicity. About 14 (31.1%) patients showed PR, 12 (26.7%) patients had stable disease (SD), whereas 19 (42.25%) patients showed progression disease (PD). Response evaluation at 6 cycles was possible in 18 patients and revealed that 4 (22.5%) patients showed PR, 10 (55.5%) patients had SD, whereas 4 (22.2%) patients had PD. Progression-free survival of the overall study population was 3.95 months.Conclusions:Eribulin mesylate is efficacious and tolerable chemotherapy as second- and third-line treatment options for MBC.

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The intraperitoneal (IP) administration of antineoplastic agents has been proposed as a method to improve the efficacy of therapy of malignant disease principally confined to the peritoneal cavity especially in carcinoma-ovary. Our patient who had more tumor burden in the peritoneum was refractory to two lines intravenous (IV) chemotherapy who improved on IP administration of platinum and IV nab paclitaxel chemotherapy regime. A 42-year-old lady was diagnosed with stage IV metastatic epithelial ovarian cancer. She suffered from progressive disease on two lines of IV chemotherapy following surgery with persistent rise in serum CA 125 level. Administration of IP platinum and IV nab paclitaxel chemotherapy regime resulted in complete (metabolic/radiological) response with normal CA 125 level. Intraperitoneal chemotherapy can be considered in patients with ovarian cancer with predominantly peritoneal disease.

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