The purpose of this research is to find out, 1) The effect of learning entrepreneur, self-efficacy and creativity together on student entrepreneurial interest, 2) The effect of entrepreneur learning on student entrepreneur interest, 3) Effect of self-efficacy on student entrepreneurial interest, 4) Effect of creativity on students' entrepreneurial interest of Tarbiyah and Teachers' Training Faculty of Universitas Islam Negeri Sumatera Utara (FITK UINSU). Type of this research is descriptive and associative research with a quantitative approach that aims to find the independent variables affect the dependent variable. The samples were selected by using proportional sampling technique which obtained that there were 185 students of 345 students as all populations. Data were analyzed by using multiple regression analysis. The results showed that, 1) entrepreneur learning, self-efficacy and creativity together have a significant and positive effect on student entrepreneur interest 2) entrepreneur learning had a significant and positive effect on students entrepreneur interests, 3) self-efficacy had a significant and positive effect on students' entrepreneur interests, and 4) creativity had a significant and positive effect on students' entrepreneur interests.