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Sol-gel technology is an impressive and instructive innovation in science that necessitates a multidisciplinary approach for its important applications in the practice. An important peculiarity of the sol gel technology is the possibility to control the mechanism and kinetics of the chemical reactions, thus monitoring the final structure (particle size, porosity, thin layer thickness) of the materials. The low processing temperature combined with the intrinsic bio-compatibility and environmental friendliness of the implied components makes it an ideal method applied in different biomedical purposes: the synthesis of porous matrices for entrapping of organic and inorganic compounds, sensor molecules, enzymes and many other biological molecules, selective coatings for optical and electrochemical biosensors, stationary phases for chromatography, immunoadsorbent and solid-phase extraction materials, controlled release agents, solid-phase biosynthesis, and unique matrices for biophysical studies. It is therefore the scope of this review to provide a few insights of the recent progresses made in sol-gel-based materials for biomedical applications.

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The study presents the possibility to prepare copolymers based on 2-hydroxyethyl methacrylate using two variants of comonomers: ethylene glycol dimethacrylate (1) and 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane (2) that act as crosslinkers for the methacrylate networks generation. The chemical structure of the copolymerssynthesized through redox polymerization process using ammonium persulfate and N,N,N′,N′-tetramethylethylenediamine as initiator pair was confirmed by FT-IR spectroscopy. The transparent gel structures were prepared in ethylene glycol. The influence of the comonomers type upon gel copolymers formation was put into evidence by the swelling behavior of the polymeric structure. The morphological information concerning the studied polymeric compounds by SEM evidenced the differences between the hydrogels with respect to cross-linker type and its amount in the monomer feed. Also the thermal stability is a function of the type and amount of the cross-linker.

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