ObjectiveTo conduct a randomized double‐blind prospective study to investigate effect of different doses of atorvastatin, rosuvastatin, and simvastatin on elderly patients with ST‐elevation AMI after PCI.MethodsOne hundred and ninety‐two AMI patients over 60 years old who underwent PCI were randomly divided into six groups: the low atorvastatin group, high atorvastatin group; low rosuvastatin group; high rosuvastatin group; low simvastatin group; high simvastatin group. Demographic data and clinical information as well as coronary angiography parameters were recorded. Plasma levels of CK‐MB, BNP, ALT, and TnI were measured at 12 hr, 24 hr, and 1 week after PCI. Major cardiovascular events (MACE) were recorded and analyzed using Kaplan–Meier (K‐M) curve.ResultsNo significant differences were observed in angiographic and procedural characteristics. In all high dose groups, all levels of CK‐MB, BNP, ALT, and TnI were significantly lower. However, after 1 week of PCI, only CK‐MB, BNP, and TnI showed significant difference between high and low dose groups. Patients in high dose groups had significantly lower rates for surgical or percutaneous intervention, recurrence of angina, and rehospitalization. K–M curve analysis also showed cumulative incidence freedom time of overall MACE in high dose groups was significantly longer. No significant differences were found among different drugs with the same doses.ConclusionPatients with higher doses had lower level of CK‐MB, BNP, ALT, and TnI and lower occurrence of MACE after PCI.

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The fibrosis-4 (FIB-4) index is a non-invasive score used to determine liver fibrosis. The present study aimed to assess the predictive ability of FIB-4 for all-cause mortality in patients with acute myocardial infarction (AMI). It retrospectively analyzed a total of 797 patients who were diagnosed with AMI. The patients were equally divided into three tertiles based on the values of the FIB-4 index scores: Group A (FIB-4 index <3.19; n=265), group B (3.19 ≤FIB-4 <8.14; n=267) and group C (FIB-4 index ≥8.14 group; n=265). Kaplan-Meier curves were used to analyze the incidence of all-cause mortality among the three groups. Multivariate Cox regression analysis was used to assess the association of risk of all-cause mortality in the patients. The Kaplan-Meier curves showed that the incidence of all-cause mortality was statistically significantly higher in group C than in groups A and B (P<0.001). After adjusting for confounding factors, multivariate Cox analysis demonstrated the risk of all-cause mortality in group C was significantly higher than in group A (hazard ratio: 2.898, 95% confidence interval: 1.069-7.857, P= 0.037). In receiver-operating characteristics (ROC) analysis, an FIB-4 index of 6.647 and a Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score of 26.75 had sensitivities of 67.3 and 55.8% and specificities of 63 and 71.9%, respectively. Comparing the area under the ROC curve revealed no statistical differences between the FIB-4 index and SYNTAX score (0.654 vs. 0.661; P=0.864). Higher FIB-4 index were associated with increased risks of all-cause mortality among AMI patients. The FIB-4 index, a noninvasive and convenient tool, plays a potential role in the prognosis of AMI.

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Background: Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between FABP1 or FABP2 and ischemic stroke.Methods: A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in FABP1 and rs1799883 polymorphism in FABP2 were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors.Results: The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (p = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060–11.103, p = 0.04). The interactions of FABP1 rs2241883 and FABP2 rs1799883 were not associated with IS risk (p = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (p = 0.011).Conclusion: The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.