Introduction: To date, there is no comprehensive systematic review and meta-analysis to assess the suitability of COVID-19 vaccines for mass immunization. The current systematic review and meta-analysis was conducted to evaluate the safety and immunogenicity of novel COVID-19 vaccine candidates under clinical trial evaluation and present a contemporary update on the development and implementation of a potential vaccines. Methods: For this study PubMed, MEDLINE, and Embase electronic databases were used to search for eligible studies on the interface between novel coronavirus and vaccine design until December 31, 2020. Results: We have included fourteen non-randomized and randomized controlled phase I-III trials. Implementation of a universal vaccination program with proven safety and efficacy through robust clinical evaluation is the long-term goal for preventing COVID-19. The immunization program must be cost-effective for mass production and accessibility. Despite pioneering techniques for the fast-track development of the vaccine in the current global emergency, mass production and availability of an effective COVID-19 vaccine could take some more time. Conclusions: Our findings invited a revisit to the reported solicited and unsolicited SAE for COVID-19 candidate vaccines. Hence, it is alarming to judiciously expose thousands of participants to COVID-19 candidate vaccines at Phase-3 trials that have adverse events and insufficient evidence on safety and effectiveness that necessitates further justification.

Background:  The novel coronavirus disease 2019 (COVID-19) outbreak, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is exponentially spreading across the globe. Methods: The current systematic review was performed utilizing electronic databases i.e. PubMed, MEDLINE and EMBASE. We searched for the keywords "COVID-19 AND "pregnancy" between January 1st, 2020 until December 31, 2020. Results: Out of 4005 records which were identified, 36 original studies were included in this systematic review. Pooled prevalence of vertical transmission was 10%, 95% CI: 4-17%. Pooled prevalence of neonatal mortality was 7%, 95% CI: 0-21%. Conclusion: The contemporary evidence suggests that the incubation period of COVID-19 is 2-14 days, and this infection could be transmitted even from the infected asymptomatic individuals. It is found that the clinical presentation of pregnant women with COVID-19 infection is comparable with the infected non-pregnant females, and the frequent symptoms were fever, cough, myalgia, sore throat and malaise. There are some cases with severe maternal morbidity and perinatal deaths secondary to COVID-19 infection. Under these circumstances, the pregnant women should focus on maintaining personal hygiene, proper nutrition and extreme social distancing to reduce the risk of COVID-19. Therefore, a systematic data reporting for evidence base clinical assessment, management and pregnancy outcomes is essential for prevention of COVID-19 infection among pregnant women.

Background: The purpose of the study is to determine the effectiveness of web-based self-care management program for type 2 diabetes mellitus through sharing evidenced-based information about Diabetes through the use of a web-based module. Materials and methods: The study used the quasi-experimental pre and posttest design to determine the effectiveness of a web-based self-care management program in the management of patients with type 2 Diabetes mellitus (DM). The study was conducted in three phases and acquired 30 purposively selected type 2 DM adult patients. The study used a web-based self-care management program that included basic information about Type 2 Diabetes mellitus using three designed modules specifically for diet, exercise and drug management. Results: The patient status during the pre and post-intervention phase is an FBS reading of 152 mg/dl or diabetes stage to pre-diabetes stage (119 mg/dl), normal BMI (22), low risk for obesity WHR and barely satisfactory to satisfactory level of knowledge to diabetes and DM management. There is very significant difference (p=<000) in the pre and post FBS reading of patients and the level of knowledge to diabetes and DM management after the web based DSME while there is no significant difference in the BMI and WHR. There is very significant difference (p=<000) in the RBS readings of the patients during the 1st, 2nd and 3rd phases of the intervention of .web based DSME (p=<000) post hoc analysis with Wilcoxon Signed Rank Test revealed that there is very significant difference (p=<000) between groups. Conclusion: The use of web-based self-care management program is effective in improving FBS/RBS and level of knowledge to diabetes and DM management of patients with type 2 diabetes mellitus but needed longer intervention to improve BMI and WHR .Nurses as part of the DSME group and as health educator may use technology in giving health education to patients to improve patients self-management to diabetes.