The co-administration of ezetimibe 10 mg with simvastatin 40 mg, by inhibiting cholesterol absorption and production, allowed more patients with acute myocardial infarction to reach LDL-C < or = 70 mg dL(-1) as early as the fourth day of treatment. The effects of such rapid and intense reduction in LDL-C on cardiovascular morbidity and mortality need to be evaluated in future clinical endpoint studies.
Objective The aim of this study is to investigate the difference in impact between distal transradial access (dTRA) and classical transradial access (TRA) on vascular function using flow-mediated vasodilation (FMD) following coronary diagnostic and therapeutic catheterizations. Methods The analysis involves a non-randomized inclusion of patients undergoing either diagnostic or elective percutaneous coronary intervention, using a dTRA access or a conventional standard TRA. Two hours after the procedure ended, the endothelium-dependent flow-mediated dilation of the brachial artery was measured by ultrasound. Results A total number of 50 patients were included. There was no statistically significant difference between the two groups (7.20% vs 6.99%, p < 0.09 for non-inferiority). Additionally, there were higher baseline values observed for BA diameters in the conventional approach group. Regarding the other secondary endpoints, there were no major access site complications, radial occlusion, in-hospital major bleeding or severe arterial spasm recorded in both groups. Conclusion Compared to conventional TRA, accessing distal radial artery for diagnostic and therapeutic coronary interventions has the same impact on short-term vascular endothelial function and was safely performed without any major vascular complications.
Aims – The objective of this study was to evaluate the feasibility of a new technique for crossing the radial artery in case of severe refractory arterial spasm. Methods and Results – We conducted a prospective, non-randomized, single center study to evaluate a new technique „Pressure Facilitated Crossing” (PFC) that can facilitate radial artery crossing with coronary catheters by injecting saline solution directly by an automated pump system trough the introducer sheath. The primary endpoint was technical success which was defined as successful catheter passage after PFC. The secondary endpoint was the rate of access-site vascular complications. From January 2018 to December 2019, 22 patients with severe and refractory radial artery spasm, with an inability to advance coronary catheters, were prospectively included in a single center. The PFC technique was used as a bailout option and was successful in 21 patients (95%). No vascular complication was noted. Overall, this strategy was well tolerated despite a short-duration of pain during saline injection. Conclusion – In case of severe radial artery spasm during transradial access, the use of the PFC technique was effective and safe for crossing the radial artery with coronary catheters after failure of conventional approaches. This bailout method has the potential to decrease the need for vascular access conversion during transradial access.
Background Percutaneous coronary intervention (PCI) of the “culprit” artery is the recommended mechanical reperfusion strategy in the setting of ST-segment elevation myocardial infarction (STEMI). As PCI of bypass grafts may be associated with higher risks and lower procedural success rates, in patients with a history of previous coronary artery surgery, PCI directed at revascularization of the native vessels should be considered, but this may be difficult in the setting of a chronically occluded artery. Case Presentation A patient with a history of multivessel coronary artery disease and a chronic total occlusion (CTO) of the right coronary artery (RCA) requiring arterial bypass surgery, presented with an acute inferior STEMI and cardiogenic shock. It was felt that shock was caused by the acute thrombotic occlusion of a right internal thoracic artery (RITA) bypass graft that had been sequentially anastomosed to the left circumflex (LCx) and right coronary arteries. Despite initiation of extracorporeal membrane oxygenation (ECMO), the patient remained in refractory shock and acute revascularization of the right coronary artery was performed through the RITA bypass segment using antegrade access to the graft through the LCx and then a retrograde approach to open a CTO of the RCA. After successful revascularization, the patient was successfully weaned from ECMO. Over 12 months of follow-up, the patient did well and was documented to have improved left ventricular systolic function. Conclusion This report is the first to document the successful use of a retrograde approach through an arterial graft segment to revascularize a chronic total occlusion in the setting of acute STEMI and cardiogenic shock.
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