Introduction: Vitamin D is involved in several human metabolismpathways, both in classic pathway, which involvesthe calcium and phosphorus metabolism, and in non-classicpathways, which are related to several types of diseases, includingdiseases related to muscles; kidneys; cardiovascular system;immune system; some types of cancer; diabetes; and pregnancy.Objectives: As cancer is one of the main health problems inthe world and knowing that it is one of the non-classic effectsrelated to vitamin D, the current narrative review aimed toverify the relevance of vitamin D has on the types of cancer.Methods: The bibliographic research was performed in databasesPubmed, Scopus and PEDro on June 16, 2020, using thekeywords “vitamin D”, “cancer” and “non-classic”. Only articlessince the year 2000 were included. Thirty-one articles wereanalyzed relating vitamin D to colon/rectum cancer, breastcancer, prostate cancer, lung cancer, ovarian cancer, melanomaand other types of skin cancer, and gastric cancer. Results: Allstudies have shown a relationship between vitamin D and theincidence of cancer in the human body, however, there arepeculiarities regarding the concentration levels in each organ.Even with conflicting results, in general, vitamin D has shownto be promise in the prevention of several types of cancer.