after long discussion on the amount of the overall 2021-2027 budget, and a last minute top-up of €4 billion for Horizon Europe thanks to the actions of the European Parliament. The new European research and innovation programme will have a budget of €95.5 billion for 2021-2027. The European Parliament and the Council also reached a deal on EU4Health, the new European Health programme with a budget of €5.1 billion. Horizon Europe is followingHorizon 2020 and keep a similar overall structure, continuing to support its main subprogrammes, but certain distinct changes are present (Table 1). 1 Pillars and clustersThe Pillar 1, named 'Excellent Science' consists of the prestigious European Research Council (ERC) grants, the Marie Slodowska-Curie Actions (MSCA), and the Research Infrastructures. The ERC grants enable outstanding researchers, at every career level, to carry out

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Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, millions of patients continue to receive insufficient diagnosis, as TB symptoms are not specific. Many existing bio-diagnostic tests are slow, have low sensitivity and/or specificity, and can be too expensive or complex for resource-limited settings. Early diagnosis of TB contributes to morbidity mitigation and prevents the disease spread. Here, we report on a new physiological pathway for TB diagnostics via TB-specific profile of volatile organic compounds (VOCs) that are detected and quantified from air trapped above the skin (“skin headspace”). Beyond the exploration aspect that relies on clinical samples from 636 individuals in two clinical sites, we demonstrate the utility of these VOC profiles in a point-of-care diagnosis, by means of specifically-designed intelligent nanoarray, both in lab setting and online, in-situ wearable devices. The results show excellent discrimination between active pulmonary TB patients and controls with 89.4% accuracy. This fulfills the triage TB test requirements according to the World Health Organization (WHO).

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