Diabetic neuropathy is a heterogeneous group that still lacks adequate comprehension. Its approach is empirical and demands exclusion of other etiologies. A definitive diagnosis is not always possible and sometimes is retrospective.
INTRODUÇÃO O sono apresenta um papel vital no crescimento e desenvolvimento das crianças sendo, no entanto, as suas perturbações frequentemente subdiagnosticadas. 1 É um processo fisiológico complexo, influenciado por propriedades biológicas intrínsecas, temperamento, expectativas, normas culturais e condições ambientais. 2 Estudos demonstram que tanto os médicos como os pais não estão, em muitos casos, preparados para iden
The authors present a case report of antituberculosis drug-induced liver injury that offered diagnostic challenges (namely, the possibility of drug-induced autoimmune hepatitis) and treatment difficulties.
Introduction: Intravenous immunoglobulin resistance occurs in 10% to 20% of cases of Kawasaki disease, resulting in a higher risk of coronary artery abnormalities. The objectives of the study were to determine predictive factors of intravenous immunoglobulin-resistant Kawasaki disease. Methods: We performed a retrospective Analytical study of Kawasaki disease patients treated by intravenous immunoglobulin in a northern Portugal hospital between 2006 and 2016. Patients were divided into two groups according to intravenous immunoglobulin response, resistant and non-resistant. Results: The study included 23 patients, 73.9% male gender, median age 19 months, of whom six (26.1%) were considered intravenous immunoglobulin-resistant. The groups did not differ in terms of gender or clinical manifestations. Significant differences were observed for age >4 years (66.7% vs 17.6%; p<0.04), duration of fever at the time of diagnosis and intravenous immunoglobulin administration (5 vs 9 days; p<0.01), lymphocytes at admission (1400 vs 4400 cells/μl, p=0.01), platelets at admission (255 000 vs 432 000 cells/μl, p<0.01), minimum haemoglobin (7.3 vs 9.9 g/dl, p<1) and minimum serum albumin (2.4 vs 3.4 g/dl, p=0.01). Echocardiographic abnormalities occurred in 34.8%
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