Our findings suggest that Type 2 diabetes mellitus in the studied rats is associated with obesity, and that both diabetes and obesity can be prevented or improved by treatment with Actinomycetales immune modulators.

El presente trabajo propone de manera aproximativa uno de los tantos modos posibles para llevar a la práctica un proceso integrador, diacrónico, sistemático y progresivamente complejo, de competencias investigativas vinculadas primordialmente al saber-hacer, pasible de aplicación en el grado y, también, al postgrado del área salud. Encuadradas en competencias del saber ser (actitudes, y valores primordialmente), aquéllas son sucesivamente conceptualizadas y detalladas según cada uno de los momentos del proceso de investigación planteados por Carlos Sabino y complementados por Ricardo Rezzónico a modo de pasos previos para su implementación. Ésta se basa en una comunicación previa sobre una experiencia decenal de un Programa optativo y extracurricular de resultados positivos y la continúa con resultados equivalentes, lo que la hace potencialmente extrapolable a los currículos de grado del área salud y a sus postgrados (carreras de especialización, maestrías y doctorados) en los que dable es presuponer mayor madurez etaria y superior cantidad de inclusores previos para más alta eficiencia.

No abstract

Obesity is a heterogeneous condition of variable aetiology, generally associated with pathologies such as arterial hypertension, hyperlipidaemia, diabetes and cardiac disease. These conditions, either themselves or because of the various treatments used, may further modify blood rheology in an arbitrary manner. Therefore, analyses of changes in the blood rheology induced by obesity in humans have had differing and controversial results. In our laboratory, a model of hypertriglyceridaemic obesity is provided by an inbred rat strain; the beta genotype from the IIMb/Fm strain, presenting a syndrome of moderate obesity with apparent peripubertal onset, associated with hypertriglyceridaemia and glucose intolerance that turns into diabetes. The alpha genotype, originated from the same IIM/Fm stock, represents the control. The present study describes a comparative analysis of the variables determining the rheological behaviour of the blood in obese and control strains. Our results, agreeing with some other studies performed in humans, confirmed the haemorheological changes associated with obesity, and the fact that these changes became more evident in the presence of pathologies such as diabetes. It appears that triglyceridaemia. cholesterolaemia and hyperglycaemia may influence the rheological behaviour of the cell membrane and this damage may provoke a decrease in erythrocyte deformability and, consequently, hyperviscosity of the blood.