Beneficial Effects of Immunotherapy with Extracts Derived from Actinomycetales on Rats with Spontaneous Obesity and Diabetes

Tarrés, María Cristina; Gayol, María del Carmen; Picena, Juan Carlos; Alet, Nicolás A.; McIntyre, Graham; Stanford, Cynthia; Stanford, J. L.

doi:10.2217/imt.12.37

Cited by 11 publications

(9 citation statements)

References 34 publications

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“…More recently, a number of these species, including Gordonia bronchialis ( G. bronchialis ), Rhodococcus coprophilus and Tsukamurella inchonensis , capable of exerting subtly different adjuvant or immunostimulatory activities in human, veterinary and agricultural medicine have been identified (Tarrés et al . ). For example, published studies with heat‐killed G. bronchialis showed that it could limit parasitaemias in rats challenged with live Trypanosoma cruzi (Fontanella et al .…”

Section: Introductionmentioning

confidence: 97%

Can heat-killed Gordonia bronchialis enhance growth and immunity in rainbow trout (Oncorhynchus mykiss )?

et al. 2016

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In this study, the efficacy of heat-killed Gordonia bronchialis on growth performance, immune system and gastrointestinal structure in rainbow trout (Oncorhynchus mykiss) was evaluated. Fish (mean weight 30 g) were fed basal diet (control), or treatment diets containing 2.48 9 10 8 (low dose) or 1.24 9 10 9 (high dose) cells kg À1 feed of heat-killed G. bronchialis on a pulse basis (5 days on treatment diet; 10 days on basal diet) for 95 days. On days 95 and 105, some of the fish were sampled for analysis of mentioned parameters. On days 110 and 120, the remaining fish were injected intraperitoneally with a 20 mL L À1 suspension of chicken red blood cells. Results showed that growth performance was significantly enhanced in both treatment groups compared with the control group. Serum complement and lysozyme activities and hemagglutination antibody titre were higher in both treatment groups compared with the control group. The length of the intestinal and pyloric caeca folds was increased in the high-dose group. Meanwhile, the number of goblet cells was increased in both treatment groups. This study suggests that heat-killed G. bronchialis has the potential to enhance growth, immunological parameters and the gastrointestinal structure in rainbow trout.

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Section: Introductionmentioning

confidence: 97%

Can heat-killed Gordonia bronchialis enhance growth and immunity in rainbow trout (Oncorhynchus mykiss )?

et al. 2016

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“…About 85% of T1DM patients are diagnosed before the age of 20 and more than 15% of this population are related to adults (30 years old). 2,3 Generally, the DM can lead various organ dysfunctions such as nephropathy, neuropathy, hepatopathy, retinopathy, and sexual failures. 4 One of the most important complications of diabetes is the disturbance in the male reproductive system which will impact more men ahead of and during their reproductive years.…”

Section: Introductionmentioning

confidence: 99%

The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

et al. 2019

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Background: This study evaluated the possible protective effects of Gordonia bronchialis (Gb) on oxidative stress and some subsequent alterations on testis from rats undergoing an experimentally induced type 1 diabetes. Methods: A total of 40 male rats were randomly divided into four groups of ten. Diabetes was induced by injection of 55 mg/kg streptozotocin in 30 rats. Oral administration of Gb at dose of 105 (low dose) and 107 (high dose) CFU/rat was performed in two groups continuously for 14 days. The third and fourth groups received normal saline as the diabetic and healthy control groups, respectively. The blood and testicular tissue samples were taken on the 14th and 21st days post treatment for biochemical and histopathological evaluations. Results: Significant differences were found in blood glucose level, insulin, IL-6 and TNF-α values together with catalase and superoxide dismutase activities and malondialdehyde level in the diabetic group in comparison with healthy and Gb recipient groups. Moreover, the histopathological lesions observed in the diabetic rats mainly included basement membrane thickening, decreased number of Sertoli cells, and severe reduction of spermatogenesis markedly attenuated in Gb-treated rats. Conclusion: Taken together, it seems that oral administration of Gb could ameliorate testicular damage associated with some related parameters in the diabetic animal model.

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“…A number of aerobic Actinomycetales species, including Rhodococcus coprophilus, Gordinia bronchialis, T. inchonensis, and closely related mycobacteria are able to exert subtly different adjuvant or immunomodulatory activities when injected as suspensions of killed bacilli (Tarres et al 2012). In animal models, preparations of T. inchonensis have been particularly successful in preventing inflammation of the intima of arteries damaged by a balloon catheter and for use in the prevention and treatment of spontaneous type 2 diabetes mellitus .…”

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confidence: 99%

Heat-killed Tsukamurella inchonensis reduces lipopolysaccharide-induced inflammatory responses in activated murine peritoneal macrophages

Nofouzi¹,

Aghapour²,

Baradaran³

et al. 2017

Vet. Med. - Czech

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Tsukamurella inchonensis (T. inchonensis)is an aerobic species of Actinomycetales which has immunomodulatory activities when used as a suspension of killed bacilli. Here, the effects of T. inchonensis on lipopolysaccharide-induced inflammatory responses in mouse peritoneal macrophages have been examined. Peritoneal macrophages were harvested by lavaging with ice cold phosphate-buffered saline. Macrophages acquired from mice treated with different doses of T. inchonensis for seven days were cultured with 20 U/ml interferon-γ and 10 µg/ml lipopolysaccharide for in vivo assays. Nitrite levels were measured by using the diazotization method based on the Griess reaction, an indirect technique to determine nitric oxide (NO) production. T. inchonensis inhibited lipopolysaccharide-stimulated NO production in mouse peritoneal macrophages from mice previously exposed to concentrations of 108 and 5 × 10 7 CFU per flask. Also, T. inchonensis decreased lipopolysaccharide-induced production of pro-inflammatory cytokines, including interleukin-6 and tumor necrosis factor-α. Thus, it can be concluded that T. inchonensis is a powerful inhibitor of lipopolysaccharide-induced NO production in activated murine macrophages, and T. inchonensis may be useful as a novel agent for chemoprevention in inflammatory diseases.

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Beneficial Effects of Immunotherapy with Extracts Derived from Actinomycetales on Rats with Spontaneous Obesity and Diabetes

Abstract: Our findings suggest that Type 2 diabetes mellitus in the studied rats is associated with obesity, and that both diabetes and obesity can be prevented or improved by treatment with Actinomycetales immune modulators.

Cited by 11 publications

References 34 publications

Can heat-killed Gordonia bronchialis enhance growth and immunity in rainbow trout (Oncorhynchus mykiss )?

Can heat-killed Gordonia bronchialis enhance growth and immunity in rainbow trout (Oncorhynchus mykiss )?

The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

Heat-killed Tsukamurella inchonensis reduces lipopolysaccharide-induced inflammatory responses in activated murine peritoneal macrophages

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