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Pulp therapy is the last resort for preserving deciduous teeth. However, the genotoxic and cytotoxic effects of many products used in this therapy are not well established. The aim of this study was to use the micronucleus test on bone marrow from mice to evaluate the genotoxic and cytotoxic effects of four filling pastes: zinc oxide, calcium hydroxide P.A., mineral trioxide aggregate and an iodoform paste (iodoform + camphorated + paramonochlorophenol + rifamycin + prednisolone). Male Swiss mice were divided into 4 groups of 10 animals, each exposed to one of the pastes, and were subdivided according to the dilutions tested: 1/10, 1/50, 1/500 and 1/1000 administered intraperitoneally (0.1ml/10g of weight). Cyclophosphamide was the positive control. The negative controls were dimethylsulfoxide and buffered saline solution. Five animals were killed 24h and five 48h after the treatment. The material was processed in accordance with Schmid (1976) and micronuclei were counted in 1000 polychromatic erythrocytes (PCE), under an optical microscope in a blinded test. Cytotoxicity was evaluated using the PCE/normochromatic erythrocyte (NCE) ratio in 200 erythrocytes. The micronucleus analysis results were evaluated using the conditional test for comparing proportions in situations of rare events. Analysis of variance and Tukey's test were used to evaluate the PCE/NCE ratio. There was significantly greater occurrence of micronuclei in the animals treated with iodoform paste at all the dilutions tested, at both sacrifice times. Greater occurrence of micronuclei was observed among the animals treated with zinc oxide and sacrificed 48h after the treatment, at the dilutions 1:50; 1:500 and 1:1000. Calcium hydroxide P.A. and mineral trioxide aggregate did not present any genotoxic or cytotoxic effects. The genotoxicity and cytotoxicity of zinc oxide and iodoform paste revealed here constitute an initial step towards their contraindication, but additional studies will be necessary in order to securely establish the risks involved in their use.

O câncer de colo de útero e mama ocupa um lugar de relevância nas taxas de morbidade e mortalidade entre a população feminina. A infecção prévia pelo Papiloma Vírus Humano (HPV) foi apontado como principal fator para desencadear o câncer de colo uterino, associada a idade precoce na primeira relação sexual, múltiplos parceiros sexuais e parceiros com múltiplas parceiras sexuais anteriores. O exame citológico cérvico vaginal é um eficiente método de detecção precoce e prevenção, além do rastreamento oportunístico para detecção do câncer de mama, ambos simples e econômico. O Programa de Assistência Integral à Saúde da Mulher constitui um conjunto de princípios e diretrizes para orientar a população feminina acima dos 10 anos de idade, incluindo ações educativas, preventivas, de diagnóstico, tratamento e recuperação. O objetivo dessa pesquisa foi identificar a atuação do enfermeiro na prevenção do câncer de colo de útero e mama, a partir das políticas públicas de saúde da Atenção Básica na cidade de Salvador-BA, no ano de 2012/2013. Os dados foram coletados por meio de entrevistas semiestruturadas, que foram gravadas e os dados analisados transcritos na íntegra, não interferindo nas respostas sendo agrupados de acordo com as respostas dadas pelos entrevistados. A rotina do profissional de Enfermagem não está organizada o suficiente para atender todas as necessidades da saúde da mulher. A má condição das estruturas físicas, na maioria das unidades,somado a carência de informação técnica e científica dos enfermeiros acabam impossibilitando a efetividade do Serviço.

Distal deletion of the long arm of chromosome 10 with breakpoints mapped at 10q26 is a well-recognized contiguous genomic disorder. A wide spectrum of clinical findings is seen in affected individuals and the common clinical features include craniofacial dysmorphia, developmental delay, intellectual disability, hypotonia, cardiovascular defects, and urogenital malformations. We report herein on a male patient with a 5.5 Mb interstitial deletion of 10q26.11q2613 and compare his clinical presentation to previously reported cases. Apart from characteristic phenotypes seen in 10q26 deletion syndrome, he presents with colobomas and left ventricle enlargement. These are cardiovascular and ophthalmological findings that have not been described in prior cases. © 2016 Wiley Periodicals, Inc.

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