<p><strong>Abstract</strong></p><p> </p><p>Dexamethasone induction may result in increased of both triglyceride synthesis and VLDL plasma level, which contribute to the increase in triglyceride level. Guava (<em>Psidium guajava)</em> consists flavonoid (quercetin) compounds that can inhibit triglyceride synthesis and decrease blood triglyceride level.</p><p><strong>Methode</strong></p><p>This research used 24 rats divided into 3 groups: group of rats fed with standard food, group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8, and group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8 and received 3 gr/kgBW guava extract for 21 days. On day 22, blood triglyceride level was measured with glycerol blanking method.</p><p><strong>Result</strong></p><p>The result of <em>Mann-Whitney U</em> showed that blood triglyceride level of group of rats induced by dexamethasone (=198.25±55.296 mg/dl) was significantly higher (p=0.001) than group of rats fed with standard food (=68.50±16.062 mg/dl). Blood triglyceride level of group of rats induced by dexamethasone and received guava extract (=98.75±26.778 mg/dl) did not significantly decreased (p=0.487) compared to group of rats induced by dexamethasone (=198.25±55.296 mg/dl).</p><p><strong>C</strong><strong>onclusion</strong></p><p>The conclusion of this research showed that dexamethasone significantly increased blood triglyceride level and guava extract tend to decrease blood triglyceride level because guava consists flavonoid (quercetin) compounds.</p><p><strong> </strong></p><p><strong>Keywords</strong>: <em>Psidium guajava, triglyceride</em>, <em>dexamethasone</em><em></em></p>