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No abstract

Although a trichilemmal cyst is a relatively common benign cutaneous condition and ossification has been observed within many cutaneous lesions to our knowledge, the association between ossification and trichilemmal cyst has not been previously reported. We describe for the first time the case of a trichilemmal cyst with marked osseous metaplasia arising on the scalp of a 46 year-old woman. Microscopically the lesion showed the typical features of a trichilemmal cyst with the finding of intra-extraluminal foci of calcification and the exceptional feature of mature bone formation. No areas of mature cartilage were observed near the focus of ossification. The cutaneous bone may have been directly formed from osteogenic stromal elements without a cartilaginous precursor (membranous or mesenchymal ossification). The dystrophic calcification might also contribute to the bone-forming process.

We report 2 cases of abnormal localized deposition of lipofuscin-laden macrophages in the lamina propria of the fallopian tube. In both cases there was evidence of ovarian and tubal endometriosis. The authors propose the term "melanosis tubae" (MT) as the most appropriate terminology in the diagnosis of the disease, whose pathogenesis is similar to that occurring in gastrointestinal tract pigmented conditions. The lesion is not of an inflammatory nature so that the term "pseudoxanthomatous salpingitis" is inaccurate and should not be used. Other definitions such as "pseudoxanthomatous salpingiosis," "pigmentosis salpingiosis," "pigmentosis tubae" may be used, but these are descriptive terms that are not suitable for denoting histogenesis. None of the previously reported MT cases showed coexisting tubal endometriosis. Our cases are the first examples of MT associated with tubal endometriosis.

These results suggest that in the absence of intraepithelial neoplastic changes, BE carries a low risk of progression to HG-IEN/BAc, and strict surveillance (or ablative therapy) is advisable in cases with endoscopic abnormalities, LG-IEN or long BE segments.