Abstract-The effect of anaerobic physical training and nandrolone treatment on the sensitivity to phenylephrine in thoracic aorta and lipoprotein plasma levels of rats was studied. Sedentary and trained male Wistar rats were treated with vehicle or nandrolone (5 mg/kg IM; twice per week) for 6 weeks. Training was performed by jumping into water (4 sets, 10 repetitions, 30-second rest, 50% to 70% body weight load, 5 days/week, 6 weeks). Two days after the last training session, the animals were killed and blood samples for lipoprotein dosage were obtained. Thoracic aorta was isolated and concentration-effect curves of phenylephrine were performed in intact endothelium and endothelium-denuded aortic rings in the absence or presence of N G -L-arginine-methyl ester. No changes were observed in endotheliumdenuded aortic rings. However, in endothelium-intact thoracic aorta, anaerobic physical training induced subsensitivity to phenylephrine (pD 2 ϭ7.11Ϯ0.07) compared with sedentary group (7.55Ϯ1.74), and this effect was canceled by the inhibition of nitric oxide synthesis. No difference was observed between trained (7.22Ϯ0.07) and sedentary (7.28Ϯ0.09) groups treated with nandrolone. Anaerobic training induced an increase in high-density lipoprotein levels in vehicle-treated rats, but there were no changes in nandrolone-treated groups. Training associated with nandrolone induced an increase in low-density lipoprotein levels but no change in the other groups. If altering endotheliumdependent vasodilatation is considered to be a beneficial adaptation to anaerobic physical training, it is concluded that nandrolone treatment worsens animals' endothelial function, and this effect may be related to lipoprotein blood levels. Key Words: aorta Ⅲ endothelium Ⅲ exercise Ⅲ lipoproteins Ⅲ nitric oxide Ⅲ phenylephrine Ⅲ rats A nabolic androgenic steroids (AAS) are formed from testosterone or one of its derivatives and present both anabolic and androgenic effects. Although the therapeutic indications of AAS are hypogonadism and protein metabolism deficiency, high doses of AAS are frequently used by persons in good health to improve physical performance and appearance, and this practice results in serious health risks. 1 With regard to the cardiovascular system, it is well known that AAS can cause stroke, 2 ischemic heart disease, myocardial infarction, 3 electrocardiographic alterations, 4 and sudden cardiac death. 5 However, there are few studies about their effects on vascular reactivity. Ferrer et al 6 observed an inhibition of endothelium-dependent and endotheliumindependent relaxation in the aortic rings of rabbits treated with nandrolone. Vasoconstrictor responses to angiotensin and tyramine, but not to noradrenaline, and vasodepressor responses to acetylcholine are reduced in testosterone-treated dogs. 7 Although it is well documented that postexercise hypotension results from a decrease in systemic vascular resistance after aerobic exercise, both in humans and animals, 8 there are no data about the vascular effects of anaero...

Objective:The objective of the study was to evaluate the safety and efficacy of atorvastatin compared with simvastatin and pravastatin in patients of hyperlipidemia.Materials and Methods:This was a randomized, parallel group, open-label study conducted at KG hospital, Coimbatore, Tamilnadu, India. Twenty hyperlipidemia patients each taking atorvastatin 20 mg, pravastatin 20 mg and simvastatin 20 mg tablets were selected for the study after clinical and baseline investigations. The patients were reviewed after 3rd and 5th month of statin therapy for lipid profile. The liver enzyme levels (SGOT, SGPT, ALP), albumin, bilirubin, protein and biochemical infraction parameters (Creatine Kinase, Creatine Kinase - Myocardial Band) after 5th month of treatment with statins were also reviewed.Results:The results showed that atorvastatin significantly reduced the lipid levels (LDL-C, TC, TG, VLDL) when compared to simvastatin and pravastatin after 3rd and 5th month of treatment. Atorvastatin increased the HDL-C levels significantly when compared to simvastatin and pravastatin after 5 months of treatment. Atorvastatin also significantly reduced the CK levels when compared to pravastatin but no increase in liver enzyme levels was observed.Conclusion:The study showed that atorvastatin is more effective when compared to simvastatin and pravastatin in patients with hyperlipidemia.

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