A comparative effect of atorvastatin with other statins in patients of hyperlipidemia

Abstract

Objective:The objective of the study was to evaluate the safety and efficacy of atorvastatin compared with simvastatin and pravastatin in patients of hyperlipidemia.Materials and Methods:This was a randomized, parallel group, open-label study conducted at KG hospital, Coimbatore, Tamilnadu, India. Twenty hyperlipidemia patients each taking atorvastatin 20 mg, pravastatin 20 mg and simvastatin 20 mg tablets were selected for the study after clinical and baseline investigations. The patients were reviewed after 3rd and 5th month of statin therapy for lipid profile. The liver enzyme levels (SGOT, SGPT, ALP), albumin, bilirubin, protein and biochemical infraction parameters (Creatine Kinase, Creatine Kinase - Myocardial Band) after 5th month of treatment with statins were also reviewed.Results:The results showed that atorvastatin significantly reduced the lipid levels (LDL-C, TC, TG, VLDL) when compared to simvastatin and pravastatin after 3rd and 5th month of treatment. Atorvastatin increased the HDL-C levels significantly when compared to simvastatin and pravastatin after 5 months of treatment. Atorvastatin also significantly reduced the CK levels when compared to pravastatin but no increase in liver enzyme levels was observed.Conclusion:The study showed that atorvastatin is more effective when compared to simvastatin and pravastatin in patients with hyperlipidemia.

Efficacy and adverse reaction to different doses of atorvastatin in the treatment of type II diabetes mellitus

“…Research conducted to evaluate the beneficial effects of ATV flagged the superior effect of ATV on reducing TC, TG and LDL-c levels compared with other HMG-CoA-reductase inhibitors, such as rosuvastatin and simvastatin [8]. Essentially, an existing study concluded that ATV could significantly lower creatine kinase levels without affecting the liver transaminase levels [18]. In addition, ATV appears optimal in respect to adverse reactions (2–9%) and safety [19].…”

Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High‐Cholesterol Diet

“…The previous data suggested that statins enhance the antioxidant status likely by inhibiting oxidative stress [ 4 , 18 ]. Our experiment reveals that there was a marked decrease in GSH-Px expression in the atherosclerotic group compared with the control group; however, treatment of the atherosclerotic group with statins would partly reverse this decline ( Figure 4(e) ).…”

“…The concentration of plasma cholesterol can be regulated by cholesterol biosynthesis, removal of cholesterol from the circulation, absorption of dietary cholesterol, or excretion of cholesterol via bile and feces. Simvastatin (HMG-CoA reductase inhibitors) and cholesterol-lowering drugs, which are now widely prescribed to patients with ischemic heart diseases, have reported that it does have antioxidant [ 15 ], anti-inflammatory [ 16 ], and immunomodulatory benefits [ 17 ] as well as its therapeutic use in hyperlipidemia [ 18 ]. However, the mechanisms underlying these benefits are not yet completely understood.…”

Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

“…Over the past decades, several research groups have focused their attention on a possible correlation between mood disorders and altered cholesterol levels both in the brain and blood (Golomb and Evans, ). In particular, statin side‐effects have been associated to several cases of irritability and violence (Golomb and Evans, ; Jose et al, ). A case report of two first‐degree male relative patients (father and son) describes behavioral adverse effects upon statin treatment including irritability and aggression which were completely reverted with the suspension of the drug (Reilly et al, ).…”