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Background: Chronic Kidney Disease (CKD) is an emerging disease that causes morbidity, mortality and affects patient's quality of life (QoL). Objectives: To assess and compare dimensions of QoL in the different stages of CKD patients and also to identify the factors affecting QoL. Data and methods: A cross-sectional study was carried out for a period of 8 months in the Dept. of Nephrology. The inclusion criterion of the study is patients above 18 years age diagnosed with CKD stage 3-5 and patients undergoing maintenance haemodialysis. The patients were assessed for QoL using European-QoL-5-dimensional (EQ-QoL-5D) and visual analog scale (VAS) questionnaires. Results: Out of 210 patients, most of the patients were in the age group 51-65 years (43.33%) and the mean age of study population was 52 ± 16.04. In the present study, most of the patients were males (79.04%). The most common comorbidities were hypertension (90%) and 51% of diabetes mellitus (DM). The mean EQ-5D index scores of the CKD stage 3, 4, 5 and 5D patients were 0.77 ± 0.09, 0.67 ± 0.10, 0.62 ± 0.12 and 0.50 ± 0.15 and the mean VAS scores for these stages were 74.10 ± 7.68, 66.52 ± 10.90, 66.45 ± 8.80 and 55.04 ± 12.82 respectively. Conclusion: The most commonly affected domains were usual activities (79%), pain (76.20%) and anxiety/depression (71.91%). Factors such as age (> 65 yrs), BMI (Underweight and Obese), educational background (Illiterate), Unemployment, domiciliary status (Rural), number of medications (> 11) had significant association with EQ-5D index and VAS scores (p-0.000). It was found that QoL was impaired in stage 5D compared to other stages (p-0.000).

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