No abstract

COCKROACH allergy is less frequent in European than in American children (1), but also less well characterized. This study was undertaken to determine whether clinical features differ among French children hospitalized for acute asthma attack according to their sensitivity to cockroach. During the last 3 years, 324 children were hospitalized for acute asthma attacks in our unit. Among children who had had skin prick tests (n=122), 34 had a positive response to Blattella germanica (monosensitive, n=13; multiple sensitive, i.e., cockroach and dust mites and/or grass pollens, n=21), and 18 others, treated as controls, were positive only for dust mites. All children were treated by the same protocol, including discontinuous salbutamol nebulizations (150 mg/kg; daily number in accordance with severity), prednisolone (1 mg/kg/day), and nasal oxygen when the value of pulsed oximetry was less than 92%. Demographic data and data on ethnic origin, and place and mode of residence were collected. The number of hospitalized episodes and days, mean hospital stay per episode, delay between the onset of the episode and the emergency room admission, the consumption of salbutamol nebulizations on the ®rst day, and the need of oxygen, intravenous salbutamol, or intensive care unit hospitalization were noted. Data, expressed as meanuSD, were compared with the Kruskal-Wallis test. The cockroach-monosensitive children were mainly black children from central Africa and the Comoro Islands (61.5% vs 14.3% for multiple sensitive children and 16.7% for dust-mite sensitive children; P=0.002). Socioeconomic status was similar between groups: parents with unquali®ed jobs in 82.3% of subjects, lowcost public housing in poor city neighborhoods in 61.7%. The 52 children were hospitalized for 73 acute asthma attacks within the 3 studied years (Table 1).Cockroach-monosensitive children had a shorter delay in hospital admission, a higher consumption of salbutamol, a higher total of hospitalized days, and a longer hospital stay per episode than children allergic to cockroach and other allergens or children with only allergy to dust mites. Follow-up and compliance were poor for all children, as only six of them, two per group, had regular scheduled medical visits and antiasthma treatments.

Realizar la descripción genética (frecuencias génicas [FG], genotípicas y haplotípicas) del sistema HLA (Human Leukocyte Antigen) en una población resulta de gran relevancia porque este conocimiento tiene implicaciones en áreas de la ciencia como en la antropología (migración, mestizaje, etc.), los trasplantes, transfusión de plaquetas, genética de las enfermedades, genética forense, desarrollo de vacunas de nueva generación, entre otras. Al finalizar una investigación en la que se determinan las frecuencias génicas o de otro tipo, éstas se deben comparar con las frecuencias estimadas previamente para la población local general, pero en muchos casos, como lo es en la población del sur de Colombia, estos datos no existen. El significado que la caracterización poblacional tenga desde el punto de vista funcional y/o práctico depende de la perspectiva investigativa desde la cual se aborde; no obstante, resulta obligatorio iniciar la descripción de las frecuencias genéticas de la población, porque esta base de datos será de mucha utilidad en futuras investigaciones y permitirá hacer posteriores injerencias tras los hallazgos, sobre el comportamiento de las enfermedades a lo largo de la historia en la región. El objetivo de esta investigación fue determinar las FG, genotípicas y haplotípicas de tres sistemas del complejo HLA, previamente tipificados mediante reacción en cadena de la polimerasa, empleando cebadores de secuencia específica (PCR-SSP). Las FG HLA-A, B y DRB1 más frecuentes (>10%) fueron: A*24 (22%), A*02 (17%), B*35 (15%), B*44 (10%), DRB1*04 (18%) y DRB1*13 (11%). Todas ellas corresponden a los alelos más frecuentes reportados en poblaciones colombianas y latinoamericanas.

Ichthyoplankton assemblages in the south central Tyrrhenian Sea are not known in spite of this being an intensely fished area. There are two large canyons in this region: Dohrn, in the Gulf of Naples, and Cuma, at the south end of the Gulf of Gaeta. In this study, we provide the first description of summer ichthyoplankton assemblages in the vicinity of the two canyons and present the physical features and Lagrangian particle tracking analyses at the time of the sampling. We identified fish larvae of 19 families and fish eggs of 8 families. The most abundant species was Engraulis encrasicolus, which was found at densities comparable to other known spawning grounds of the western Mediterranean. Mesopelagic species, such as Gonostomatidae and Myctophidae, were also abundant, especially at the Cuma Canyon. The notochord and standard length of the E. encrasicolus larvae ranged from 2.06 to 10.47 mm and was significantly smaller at the Cuma stations than at the Dohrn stations, suggesting the presence of sub-populations with different spawning phenologies. The passive particle tracking analyses and the examination of currents confirmed distinct circulation features between the two sampled regions and in relation to depth and proximity to the canyon heads. These results uncover previously unknown rich assemblages of fish eggs and larvae and have conservation and management implications given the proximity of these canyons to a marine protected area and to an intensely fished continental shelf.

Table of contentsWORKSHOP 4: Challenging clinical scenarios (CS01–CS06)CS01 Bullous lesions in two children: solitary mastocytomaS. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal GokCS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experienceJessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise MichaelisCS03 Cold urticaria in pediatric age: an invisible cause for severe reactionsInês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-AlmeidaCS04 Angioedema with C1 inhibitor deficiency in a girl: a challenge diagnosisCristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José OliveiraCS05 A child with unusual multiple organ allergy disease: what is the primer?Fabienne Gay-CrosierCS06 A case of uncontrolled asthma in a 6-year-old patientIoana-Valentina Nenciu, Andreia Florina Nita, Alexandru Ulmeanu, Dumitru Oraseanu, Carmen ZapucioiuORAL ABSTRACT SESSION 1: Food allergy (OP01–OP06)OP01 Food protein-induced enterocolitis syndrome: oral food challenge outcomes for tolerance evaluation in a Pediatric HospitalAdrianna Machinena, Olga Domínguez Sánchez, Montserrat Alvaro Lozano, Rosa Jimenez Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, Mª Teresa Giner Muñoz, Marcia Dias da Costa, Ana Maria Plaza MartínOP02 Characteristics of infants with food protein-induced enterocolitis syndrome and allergic proctocolitisEbru Arik Yilmaz, Özlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Cansin SackesenOP03 The clinical and immunological outcomes after consumption of baked egg by 1–5 year old egg allergic children: results of a randomised controlled trialMerrynNetting, Adaweyah El-Merhibi, Michael Gold, PatrickQuinn, IrmeliPenttila, Maria MakridesOP04 Oral immunotherapy for treatment of egg allergy using low allergenic, hydrolysed eggStavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella M. Montagner, Maria Passioti, Nicolò Celegato, Selina Summermatter, Sophie Nutten, Tristan Bourdeau, Yvonne M. Vissers, Nikolaos G. PapadopoulosOP05 Chemical modification of a peanut extract results in an increased safety profile while maintaining efficacyHanneke van der Kleij, Hans Warmenhoven, Ronald van Ree, Raymond Pieters, Dirk Jan Opstelten, Hans van Schijndel, Joost SmitOP06 Administration of the yellow fever vaccine in egg allergic childrenRoisin Fitzsimons, Victoria Timms, George Du ToitORAL ABSTRACT SESSION 2: Asthma (OP07–OP12)OP07 Previous exacerbation is the most important risk factor for future exacerbations in school-age children with asthmaS. Tolga Yavuz, Guven Kaya, Mustafa Gulec, Mehmet Saldir, Osman Sener, Faysal GokOP08 Comparative study of degree of severity and laboratory changes between asthmatic children using different acupuncture modalitiesNagwa Hassan, Hala Shaaban, Hazem El-Hariri, Ahmed Kamel Inas E. MahfouzOP09 The concentration of exhaled carbon monoxide in asthmatic children with different controlled stadiumPapp Gabor, Biro Gabor, Kovacs CsabaOP10 ...