Highlights The toxic effects of diclofenac (DF) seemed to be sustained after withdrawal. DF appeared to be more toxic post-administration. Melatonin could attenuate the toxic effects of DF.

Background and objectives: Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in VEGFA and other loci were shown to explain more than 50% of its circulating levels. This study investigated the association of those ten VEGF-related SNPs with serum iron levels in a general Lebanese population free of chronic diseases (N = 460). Result: We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (p = 0.002, and p < 0.001, respectively). When taken together, both variables, rs10738760 and BMI, interacted to reduce iron levels (p < 0.001). According to obesity status, the stratification revealed that the effect of rs10738760 was more pronounced in obese than nonobese individuals (p = 0.025). Conclusion: The intergenic SNP rs10738760 is associated with circulating iron levels, and this association depends on BMI status. Although of interest, these results need replication in larger populations from different ancestries.

The aim of this study is to demonstrate the association of the fat-mass and obesity associated gene (FTO) polymorphisms with type 2 diabetes (T2D) and the various aspects of BMI in Egyptian patients. FTO quality polymorphism was distinguished utilizing PCR-RFLP in 40 patients with type 2 diabetes mellitus (DM) and 40 evidently sound control subjects. All members were exposed to clinical assessment including estimating systolic and diastolic circulatory strain, BMI, midsection perimeter (WC), neck circuit (NC) and abdomen hip proportion (WHR) and evaluation of both quantitative insulin affectability check record (QUICKI) and HOMA-IR. People with AA genotype were 6.8 occasions bound to have DM than TT genotype patients. T allele was viewed as a defensive factor while An allele was a free hazard factor for T2DM. AA and AT genotypes are noteworthy indicators of type 2 diabetes mellitus. There was noteworthy increment in BMI, NC, WHR (in females) and WC (in guys) in AA genotype bunch contrasted with TT and AT genotype gatherings. HOMA-IR was distinguished higher in AA genotype bunch contrasted with TT and AT genotype gatherings. An allel of (FTO rs9939609) quality polymorphism was seen as altogether connected with expanded danger of T2D and expanded BMI in Egyptian patients.

In recent years, many cities and rural areas are facing frequent waterlogging, run-off pollution, huge loss of resourceful rainwater, damaged ecosystem and many more rain water related problems. In regional perspective, how to construct a sustainable storm water management measures have been presented as an important issue in many cities and urban agglomeration in Nigeria. Ibeju Lekki area is usually faced with the problem of rain water leading to incessant flooding. This study therefore assesses storm water management in Ibeju-Lekki Area, Lagos state. The research employs a random sampling technique in selecting 204 (0.07  ) respondents for questionnaire administration. Descriptive and inferential statistical tools were employed in the analysis of the data. Pearson product moment correlation was used to test the relationship between the gradient analysis and vulnerability to runoff of Ibeju-Lekki. Also, the slope analysis of the study area was carried out using slope calculation. Findings revealed that natural green space, public parks and gardens and drainage system were the most available storm water management infrastructure in the area. The result of correlation analysis with r = 0.971 shows a strong positive correlation between gradient and vulnerability to runoff. The study concluded that physical planning policies such as thorough monitoring of building plan before approval and institution of effective development control agencies among others should be put in place to ensure proper management of storm water in Ibeju-Lekki local government area of Lagos state

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