The aim of this study is to demonstrate the association of the fat-mass and obesity associated gene (FTO) polymorphisms with type 2 diabetes (T2D) and the various aspects of BMI in Egyptian patients. FTO quality polymorphism was distinguished utilizing PCR-RFLP in 40 patients with type 2 diabetes mellitus (DM) and 40 evidently sound control subjects. All members were exposed to clinical assessment including estimating systolic and diastolic circulatory strain, BMI, midsection perimeter (WC), neck circuit (NC) and abdomen hip proportion (WHR) and evaluation of both quantitative insulin affectability check record (QUICKI) and HOMA-IR. People with AA genotype were 6.8 occasions bound to have DM than TT genotype patients. T allele was viewed as a defensive factor while An allele was a free hazard factor for T2DM. AA and AT genotypes are noteworthy indicators of type 2 diabetes mellitus. There was noteworthy increment in BMI, NC, WHR (in females) and WC (in guys) in AA genotype bunch contrasted with TT and AT genotype gatherings. HOMA-IR was distinguished higher in AA genotype bunch contrasted with TT and AT genotype gatherings. An allel of (FTO rs9939609) quality polymorphism was seen as altogether connected with expanded danger of T2D and expanded BMI in Egyptian patients.