Introduction. Empyema thoracis, defined as the accumulation of pus in the pleural space, is rare in neonatal population. There are limited data reported in the medical literature and there are still no treatment guidelines available for this age. Case report. We present a healthy term 12-day-old neonate with sepsis caused by methicillin-resistant Staphylococcus aureus (MRSA) and pneumonia associated with advanced stage empyema. The child was admitted to our hospital with a few-hours history of difficulty breathing and lethargy. At the admission, the child was cyanotic with desaturation, in severe respiratory distress, so it was intubated and started mechanical ventilation. Imaging tests were performed in emergency, therefore chest computed tomography (CT) scan was done without contrast. Suspected congenital pulmonary airway malformation (CPAM) with trapped air collections, significant mediastinal shift on CT scan and deterioration of the patient?s condition indicated urgent surgery. Intraoperatively, the diagnosis of stage 2 empyema was established, and decortication of thickened parietal and visceral pleura was performed. Afterwards the baby showed quick and progressive clinical improvement. Conclusion. The diagnosis and management of empyema in neonates may be a challenging one, especially in the case of unremarkably history, fulminant and rapid progression of the disease and incomplete imaging tests.

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Introduction. SARS-CoV2 2019 infection represent global problem. At this moment there is no vaccine or efficient treatment of infected patients. Treatment with blood plasma rich with anti SARS-CoV2 specific antibodies represents rare safe and effective treatment of Covid19 patients. Patients and Material. A total number of 950 patients were analyzed in this study, whose samples were collected in time interval from 01.05. till 15.08.2020. Patients were enrolled in study from Covid-19 hospitals, out-clinics and as family members of SARS-CoV2 infected patients. Original ELISA tests were developed to measure the concentration of anti-S1S2 Spike and anti-Nucleoprotein (IgG, IgA, IgM) SARS-CoV2 antibodies. Blood convalescent plasma was selectively collected from recovered patients according to specific antibodies concentration. Results. The highest concentrations of anti-S1S2 Spike or anti-Nucleoprotein specific IgG antibodies were detected in patients with the moderate/heavy clinical form of infection as well as in group of family members of SARS-CoV2 infected patients. Extremely high concentration of anti S1S2 Spike IgG and anti-Nucleoprotein IgG was demonstrated in 3% and 6% (respectively) of patients recovered from severe Covid19. From our hospitalized patients 63% and 51% had modest antibody levels (anti S1S2 Spike and anti-Nucleoprotein, respectively). After 60 days, in our selected donors? concentration of anti S1S2 Spike IgG antibodies increased in 67%, paralleled with increase of anti-Nucleoprotein IgG antibodies in 58% of donors. Conclusion. Originally developed ELISA tests enable novel protocol for selection of convalescent blood plasma donor.