Supplementary key words cancer • dyslipidemias • lipids • lipoproteins • LDL subfractionsAcute lymphoblastic leukemia (ALL) constitutes more than 80% of newly diagnosed acute leukemias in children and has a current fi ve-year overall survival rate exceeding 85 percent ( 1 ). At the same time, data from the Childhood Cancer Survivor Study (CCSS) suggest that adult survivors of childhood leukemia are at signifi cantly increased risk for myocardial infarction [Hazard rate (HR) 3.3; 95% CI, range 1.2-8.6 ] and congestive heart failure (HR 4.2; 95% CI, range 2.3-7.4) compared with their noncancer siblings ( 2, 3 ). Therefore, it is imperative to identify potential cardiac risk factors in this population at an early stage in the atherosclerotic process.Low-density lipoprotein (LDL) is composed of multiple subfractions based on particle size and density. Among these LDL subfractions, small dense LDL is more atherogenic than larger particles ( 4 ) and is associated with an increased risk for coronary artery disease (CAD) ( 5 ). There are two main subclass patterns of LDL based on predominant LDL particle size: large, buoyant LDL pattern A (particle diameter у 25 nm) and small dense LDL pattern B (particle diameter < 25 nm) ( 6 ). LDL pattern B is independently associated with higher rate of CAD progression

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