A case of cerebral cryptococcosis is described. Cryptococcus neoformans is the most pathogenic in humans. It often affects lungs, skin, muscles and tissues of the Central Nervous System (CNS). In case of CNS involvement, the main clinically diagnosed form of the disease is cryptococcal meningitis. The authors describe a patient with non-specific symptoms of anxiety-depressive disorder and further development of neurological symptoms and behavioral deviations.

Introduction In Russia, the prevalence of GERD is 18-46% [Ivashkin V. T., Maev I. V., Trukhmanov A. S., 2011]. GERD leads to a significant decrease in the quality of life of patients, especially with nocturnal symptoms, extraesophageal symptoms (chest pain, persistent cough), and increases the risk of complications such as bleeding from ulcers and erosions, peptic strictures and, which causes the greatest caution, Barrett’s esophagus and esophageal adenocarcinomasObjectivesThe medical and social significance of the pathology of the thyroid gland and gastrointestinal tract problem is determined by their high prevalence regardless of age, the annual increase in morbidity and the decrease in the quality of life (QOL).MethodsPatients were divided in two groups: patients with GERD; patients with GERD and hypothyroidism. Quality of life was studied using the non-specific (general) SF 36 questionnaire.ResultsThe lowest indicators were shown by patients with GERD and hypothyroidism (PF scale - Me 75.00 and 45.00 (p=0.005470), RF scale - 75,00 and 25.00 (p=0.043046), BP scale - 74.00 and 52.00 (p=0.036493), GH scale - 58.00 and 15.00 (p=0.009959)). The second group was more disadvantaged (VT scale - IU 52.50 and 32.50 (p=0.098125), SF scale - 75 00 and 50.00 (p=0.019016), RE scale - 33.30 and 0.00 (p=0.028841), GH scale - 48.00 and 36.00 (p=0.025919).ConclusionsAccording to the results, the presence of combined pathology of the thyroid gland and gastrointestinal tract significantly affected the physical and psychological component of health in the studied patients.

No abstract

IntroductionHepatitis C virus (HCV) infection produces a chronic systemic disease that induces chronic hepatitis, cirrhosis and hepatocellular carcinoma. Patients with chronic HCV infection may present with a range of extrahepatic symptoms including neuropsychiatric disorders.ObjectivesThe aims of this review are to summarize recent literature looking at the associations between psychosocial and neurocognitive factors and HCV, identify the most common neuropsychological disorders and consider the probable mechanisms of mental and cognitive impairment in patients with HCV.MethodsPubMed/Medline was systematically searched for psychosocial and neurocognitive factors associated with hepatitis C and patient wellbeing. In this review 83 valid articles were analyzed from 1994 to 2018.ResultsAccording to the literature review in the group of HCV-positive patients were found a significant decrease in higher cognitive functions: memory impairment, concentration and listening. These manifestations of cognitive dysfunction are supposed to be similar to the early symptoms of Alzheimer’s disease. An increased risk of developing dementia has also been noted. The most frequently diagnosed symptoms were fatigue and sleep disturbances, associated with mood disorders diagnosed in 19,2% of cases. Several mechanisms have been considered to explain the pathogenesis of neuropsychiatric disorders observed in chronic HCV infection: 1) the concept of the direct neuroinvasion of HCV; 2) derangement of metabolic pathways; 3) cerebral or systemic inflammation.ConclusionsTo date, the mechanisms of various mental and neurological disorders in patients with chronic HCV infection have been partially identified, but the long-term effect of these changes requires further study.