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[1] Phlegrean Fields is an active and densely populated caldera near Naples (Italy). Two major unrest episodes characterized its recent history, each leading to remarkable ground uplift and followed by slow subsidence. Fumaroles near the caldera centre underwent important chemical changes during these volcanic crises. Based on published data we show that a correlation exits between ground displacement and gas composition. Numerical modelling of hydrothermal circulation shows that periods of enhanced fluid injection at the base of the hydrothermal system, are consistent with the observed chemical variations. The model predicts an average increase in pore pressure and temperature within the system, suggesting potential effects on ground deformation. Literature data and simulation results show that periods of intense magmatic degassing could explain most of the features characterizing recent bradyseismic crises and should be considered a potential trigger for the unrest at Phlegrean Fields, as well as at other calderas in the world.

The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker predicting the prognosis of several diseases. We aimed to assess its role as a predictor of mortality or admission to the intensive care unit in COVID-19 patients. We retrospectively evaluated a cohort of 411 patients with COVID-19 infection. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) of patients with COVID-19 were compared. The median age of our sample was 72 years (interquartile range: 70–75); 237 were males. Hypertension, diabetes and ischemic heart disease were the most common comorbidities. The study population was subdivided into three groups according to NLR tertiles. Third-tertile patients were older, showing significantly higher levels of inflammatory markers; 133 patients (32%) died during hospitalization, 81 of whom belonged to the third tertile; 79 patients (19%) were admitted to ICU. NLR showed the largest area under the curve (0.772), with the highest specificity (71.9%) and sensitivity (72.9%), whereas CRP showed lower sensitivity (60.2%) but slightly higher specificity (72.3%). Comparisons between NLR and CRP ROC curves were significantly different (p = 0.0173). Cox regression models showed that the association between NLR and death was not weakened after adjustment for confounders. Comparisons of ROC curves showed no significant differences between NLR, PLR, and CRP. Cox regression analysis showed that NLR predicted the risk of admission to ICU independently of demographic characteristics and comorbidities (HR: 3.9597, p < 0.0001). These findings provide evidence that NLR is an independent predictor of mortality and a worse outcome in COVID-19 patients and may help identify high-risk individuals with COVID-19 infection at admission.

Acute and long-term results demonstrate that cryoablation of AVNRT can be considered a safe and effective procedure in pediatric patients. (PACE 2010; 475-481).