-The clinical and neurological findings of three neonates with the diagnosis of cerebrovascular disease are reported. The neuropsychological evaluation disclosed impairment of fine motor function, coordination, language, perception and behavioral disturbances. Brain SPECT imaging revealed perfusional deficits in the three cases.KEY WORDS: neonates, stroke, cerebrovascular disease, brain SPECT imaging. Doença cerebrovascular em recém-nascidos : relato de três casos com estudo clínico evolutivo e SPECT cerebralRESUMO -Os resultados dos estudos clínico e neurológico de três recém-nascidos com diagnóstico de doença cerebrovascular são apresentados. A avaliação neuropsicológica demonstrou alterações na motricidade fina, coordenação, linguagem, percepção e comportamento. O SPECT cerebral mostrou alterações perfusionais nos três recém nascidos.PALAVRAS-CHAVE: recém-nascido, icto neonatal, doença cerebrovascular, SPECT cerebral.In the past decade, new methods of cerebral function evaluation using different imaging modalities have acquired expressive development and clinical relevance. In cerebrovascular diseases (CVD) the demonstration of blood flow and metabolic abnormalities in local and remote areas (diaschisis) 1,2 is possible. In spite of this progress, brain SPECT imaging has not been used routinely in newborns and infants, especially those with confirmed diagnosis of CVD in the first days of life. A better understanding of the regional cerebral metabolism may be achieved using brain SPECT imaging as a complementary diagnostic modality.The clinical and laboratory data of three newborns with neonatal CVD have been reviewed with the purpose of: a) to determine the magnitude of anatomic and functional impairment caused by the acute event (stroke); b) to correlate prospectively the neurologic and cognitive findings with brain SPECT imaging data.