The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and westernblotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ERα); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ERα and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. HIGHLIGHTS• Brazilian berry mitigate the disorder onset in prostate of senile/high-fat mice.• Brazilian berry reduced AR/ERα/IGFR-1 labeling in prostate of senile/high-fat mice.• Brazilian berry preventive effect increases according to the prostatic damages rise.
ResumoO presente estudo teve como objetivos avaliar os efeitos do envelhecimento e do consumo de dieta hiperlipídica na biologia estrutural e molecular do lobo anterior da próstata (glândula de coagulação) de camundongos FVB; e verificar o efeito do tratamento com extrato da casca da Jabuticaba (ECJ) na possível reversão ou amenização dos danos gerados por estes fatores. Os animais senis apresentaram aumento da proliferação celular e atrofia epitelial, enquanto que os animais senis que consumiram a dieta hiperlipídica mostraram intensificação da atividade proliferativa e redução do epitélio sem alteração morfológica. O consumo do ECJ por animais senis promoveu redução nas regiões de atrofia epitelial e aumento do pregueamento regular dos ácinos. Em animais senis que consumiram a dieta hiperlipídica e o ECJ, verificou-se um aumento de tecido epitelial sem alteração, uma redução da proliferação celular, além de aparente diminuição da atrofia epitelial. De maneira geral, o tratamento com ECJ mostrou-se positivo, uma vez que possibilitou a recuperação das características normais do epitélio prostático no lobo anterior, submetidas à ação lesiva da senescência e exposição à dieta rica em lipídios.
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