Clinical evaluation of lysuride in the management of hyperprolactinaemia Bromocriptine is a semisynthetic ergot alkaloid that acts as a dopamine agonist and is highly effective in achieving normoprolactinaemia in most patients with raised serum prolactin concentrations. Some patients, however, may have unacceptable side effects. Lysuride hydrogen maleate (lisuride; Revanil, Schering UK) is an 8-a-ergolene which has potent dopamine agonist activity both in vitro and in vivo'; currently there are few data available about the incidence of side effects with lysuride in relation to its clinical efficacy. We have therefore assessed the efficacy of lysuride in 24 consecutive women presenting with hyperprolactinaemia. Patients, methods, and results All 24 patients (age range 19-42) presented with a serum prolactin concentration (mean of three estimations) above 360 mU/I, which is the upper limit of normal in on 17 October 2020 by guest. Protected by copyright.

Clinical evaluation of lysuride in the management of hyperprolactinaemia Bromocriptine is a semisynthetic ergot alkaloid that acts as a dopamine agonist and is highly effective in achieving normoprolactinaemia in most patients with raised serum prolactin concentrations. Some patients, however, may have unacceptable side effects. Lysuride hydrogen maleate (lisuride; Revanil, Schering UK) is an 8-a-ergolene which has potent dopamine agonist activity both in vitro and in vivo'; currently there are few data available about the incidence of side effects with lysuride in relation to its clinical efficacy. We have therefore assessed the efficacy of lysuride in 24 consecutive women presenting with hyperprolactinaemia. Patients, methods, and results All 24 patients (age range 19-42) presented with a serum prolactin concentration (mean of three estimations) above 360 mU/I, which is the upper limit of normal in