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SUMMARY Inheritance of Glm(z) without Glm(a) was found in five members of a Newfoundland family. The investigations were suggestive for the transmission of a Gm haplotype (z; n‐; g) coding for Glm(z) and nGlm(a) at the Fd and Fc parts, respectively, of the IgGl heavy chain.

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Summary:Fertility is expected to be reduced after the extensive chemotherapy and/or radiotherapy that is needed for conditioning prior to bone marrow transplantation. However, a male patient can be fertile, and in very rare situations such as reported here, this may confuse subsequent paternity testing. The patient, initially excluded as the biological father by red cell types but not by HLA, was subsequently included after the history of his previous marrow transplant was revealed, a review of the HLA results and further RFLP testing on buccal mucosal cells. This case points to the need for good history taking before performing paternity testing. Keywords: parentage testing; paternity; allogeneic bone marrow transplant; fertility Although bone marrow transplantation is a therapeutic modality that results in long-term disease-free survival and perhaps cure for many patients with hematological malignancies that would otherwise be fatal, the survivors are faced with many issues that prove to be difficult particularly for younger individuals, over their remaining lifetime. One of these is infertility. The actual incidence of this as a problem is difficult to quantitate, as the denominator of this equation is uncertain, that is to say the number of women who actually wish to conceive is not known and in the case of males, it is not the usual practice to study genetic status of the progeny of a successful conception to determine who actually fathered the child. More has been published on female fertility than on male, as it is clear when the surviving transplant patient has been pregnant and delivered a child. This still remains an uncommon event. 1,2 In the case of male fertility even less is reported and in only three cases of which we are aware, was the paternity actually determined by genetic typing; one father had received an autologous transplant 3 and the others allogeneic transplants. 4,5 We now report a case where the paternity of a transplanted man was (eventually) recognised during the course of testCorrespondence: JH Lipton, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9 Received 13 May 1998; accepted 30 July 1998 ing in a case of disputed paternity. This appears to be the first report of its kind and underlines the need for paternity testing laboratories to be aware when bone marrow transplants have been performed. Case reportPaternity testing was requested in 1996 by a 27-year-old man (applicant). In this case, he was attempting to prove his paternity rather than to deny it. He had become involved with a woman who was in the process of separating from her husband. She became pregnant, delivered a healthy child, was not interested in raising it and had it placed in a foster home. The applicant was particularly keen to have custody of the child; however, he was told that he could not do so unless he could show that it was his child. Standard testing was performed including HLA typing, ABO, Rhesus, MNS, Kidd, Duffy and Kell blood groups as well as Factor B and C3 of the...