Earlier papers of this series described N10alkylla and 9-methyllb analogs of pteroylglutamic acid which exhibited antagonistic action against the latter in the growth of Streptococcus faecalis R. The present paper is concerned with derivatives in which the 4-hydroxyl of the pteridine nucleus is replaced by the amino group. The synthesis of the 4-amino analog of pteroylglutamic acid was announced in a preliminary communication23 and subse-O quently a number of references have been made to this compound and its biological properties.213-11 The 4-amino derivatives are powerful antagonists for

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