The design and synthesis of high-affinity FKBP 12 ligands is described. These compounds potently inhibit the m-rrans-peptidylprolyl isomerase (rotamase) activity catalyzed by FKBP 12 with inhibition constants (Ki,app) as low as 1 nM, yet they possess remarkable structural simplicity relative to FK506 and rapamycin, from which they are conceptually derived. The atomic structures of three FKBP12-ligand complexes and of one unbound ligand were determined by X-ray crystallography and are compared to the FKBP12-FK506 and FKBP12-rapamycin complexes.

Surface acoustic waves (SAWs) in the GHz frequency range are exploited for the all-elastic excitation and detection of ferromagnetic resonance (FMR) in a ferromagnetic-ferroelectric (Ni/LiNbO(3)) hybrid device. We measure the SAW magnetotransmission at room temperature as a function of frequency, external magnetic field magnitude, and orientation. Our data are well described by a modified Landau-Lifshitz-Gilbert approach, in which a virtual, strain-induced tickle field drives the magnetization precession. This causes a distinct magnetic field orientation dependence of elastically driven FMR that we observe in both model and experiment.

We present a wet chemical process for nanoscale texturing of Si surfaces, which results in an almost complete suppression of the reflectivity in a broad spectral range, leading to black Si surfaces. The process affects only the topmost 200–300nm of the material and is independent of the surface orientation and doping. Thus, it can be applied to various structural forms of bulk silicon (single, poly-, or multicrystalline) as well as to thin Si films (amorphous or microcrystalline). The optical properties of various black Si samples are presented and discussed in correlation with the surface morphology.