Background Intensive care unit (ICU) survivors face complex physical, cognitive, and psychological sequelae that can negatively impact their health-related quality of life. To date, the association between ICU survivors’ psychological sequelae, individual care needs, and discharge disposition has not been evaluated. Objective To describe depressive symptoms and anxiety in ICU survivors and explore these symptoms based on individual care needs and home discharge status for 4 months post-ICU discharge. Methods We analyzed data from 39 ICU survivors who self-reported measures of depressive symptoms (Center for Epidemiologic Studies-Depression 10 items [CESD-10]) and anxiety (Shortened Profile of Mood States-Anxiety subscale [POMS-A]) at one or more of the following time points post-ICU discharge: within 2 weeks, 2 months and 4 months. Results A majority of patients reported CESD-10 scores above the cut off (≥8) indicating risk for clinical depression: 83.9% within 2 weeks (26 of 31), 64.3% at 2 months (18 of 28) and 72.0% at 4 months (18 of 25). POMS-A scores were highest within 2 weeks of ICU discharge (8.9±3.5; n=33) and decreased over time (7.0±3.0 at 2 months, n=28; 6.6±2.7 at 4 months, n=25). Data trends suggest worse depressive symptoms and anxiety when patients had moderate to high care needs and/or were unable to return home. Conclusion In our sample, ICU survivors who need caregiver assistance and extended institutional care reported trends of worse depressive symptoms and anxiety. Early screening and treatment of psychological symptoms may be an important means to promote rehabilitation and recovery.