The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P<0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients.

BackgroundVaginal flora of healthy women is dominated by Lactobacillus species which can prevent bacterial vaginosis.ObjectivesThe current study aimed to determine the differences in vaginal lactobacilli composition of Iranian healthy and bacterial vaginosis (BV) infected women and compared their cytotoxic effects with commercial vaginal probiotics.Patients and MethodsOne hundred and seventy eight vaginal specimens were collected from healthy and BV infected women. Lactobacillus colonies were obtained by culturing on laked blood BHI and MRS medias and genetically defined by 16s rRNA sequencing. Differentiating the specimens to normal, intermediate and BV infected were carried out by Ison and Hey grading protocol. Identification of Lactobacillus strains in vaginal specimens were performed by Multiplex PCR. The inhibitory effects of lactobacilli on Hela (tumoral cervical cells) and HNCF-pi52 (normal cervical cells) were conducted by MTT and trypan blue assays.ResultsL. crispatus, L. gasseri, L. iners, L. jensenii, L. acidophilus and L. rhamnosus were the most frequently occurring species in vagina of healthy Iranian women. L. crispatus and L. jensenni were significantly higher in the normal than in the BV infected groups. Also the cytotoxic effect of L. crispatus on tumoral cervical cells was higher than other lactobacilli including commercial probiotics.ConclusionsAs L. crispatus and L. jensenni were significantly higher in BV infected women and the cytotoxic effect of L. crispatus on tumoral cervical cells was high, introduction of new probiotics seems necessary.

Aims: Sore throat, hoarseness, and cough are postoperative complications caused by tracheal intubation in general anesthesia. The aim of this study was to investigate the role of preoperative ketamine splashing on reducing postoperative sore throat. Study Design: A cross-sectional/ randomized, double-blinded clinicall study.

This study was conducted to investigate the effect of milk supplemented with organic iron on performance, blood hematology, iron metabolism parameters, biochemical and immunological parameters in suckling lambs. Thirty-six newborn Dalagh lambs were randomly divided into three groups with 12 replications. The control group was fed with milk without organic iron. The other two groups were fed milk supplemented with 25 and 50 mg/d organic iron, respectively. During the experiment, increased daily weight gain and total body weight were observed in the iron-supplemented groups. An increase in the levels of red blood cell, hemoglobin, hematocrit, mean corpuscular hemoglobin, and mean corpuscular concentration in iron supplemented groups was indicated. Consumption of organic iron caused a significant decrease in plasma copper concentration. Total antioxidant status level was lower, but levels of glutathione peroxidase, superoxide dismutase, and catalase were higher in iron supplemented groups. In organic iron supplemented groups, insulin and thyroid hormones levels were significantly increased, and glucose level was significantly decreased. In organic iron supplemented groups, alkaline phosphatase level significantly increased, and aminotransferase level significantly decreased. Overall, the use of organic iron in the milk improved the performance and health in suckling lambs, and since a lower level of supplementation is naturally preferable, supplementation of milk with 25 mg/d organic iron is recommended.

Purpose: To compare the chromatic contrast sensitivity function (CSF) for the blue-yellow opponent channel (BYOC) between female badminton players and non-athlete controls. Methods:We recruited 40 young females (18-25 years old) who played badminton for at least 5 consecutive years as the test group, and 30 age-matched female controls who had no history of regular physical activity. The Pattern Generator™ system was used to test the CSF for the BYOC which was performed at three spatial frequencies (SFs) of 2 cycles per degree (cpd), 5 cpd, and 25 cpd. Results:Comparison of BYOC thresholds showed significantly better results in the test group for all three SFs (P<0.001). Band pass shift (better CSF in the middle SF) was seen in the test group. The control group had low pass (better CSF in the low SF). Ocular motility (heterophoria, fusional convergence and divergence at far and near distances, and near point of convergence) was better in the test group, but the inter-group difference was not significant. Conclusions:The BYOC threshold results for badminton players indicated a better visual performance which may be a result of enhanced performance of the parallel processing of the parvocellular and magnocellular systems. This may be inherent and/or acquired in badminton players. In addition, badminton players appear to have developed sensory-motor programmed activities. Testing the CSF for BYOC may be useful for athlete selection in different levels and/or used as a criterion for screening players in the field of badminton.