Introduction: The mediastinal space is confined from the top to the thorax inlet, at the bottom with the diaphragm. Presentation of case: A female with a right lung tumor with a history of chemotherapy, intubation, mediastinal fixation was performed on the affected side due to inadequate lung expansion, treatment-resistant fistula and intolerance of surgery to the pulmonary fistula. By fixing the mediastinal space on the affected side, right pleural space was drained. Conclusion: It is recommended that patients undergoing surgery for chronic empyema due to immunodeficiency and refractory infections, who do not tolerate surgery due to chronic pleural effusion and cavitation due to loculated Empyema develop thoracic surgery, fixation and continued treatment should be performed.

Introduction and importance: Pneumonectomy is commonly associated with cardiopulmonary complications. Pneumonectomy in Pancoast tumor with mediastinal extension and no metastasis could be successful and efficient. Case presentation Herein, we report a successful pneumonectomy of a 54-year-old man with pancoast tumor along with the involvement of mediastinal space including right hilum of the lung, right bronchial, inferior vena cava vein and pericardium. Clinical discussion Based on the bronchoscopy and biopsy, the complete involvement of right bronchial tree was reported and non-small cell carcinoma was diagnosed in pathology. Conclusion To reduce the complications of the surgery, the cardiopulmonary pump machine was used during the operation.