Currently the whole world is going through a health contingency due to the COVID-19 disease, a situation that has triggered countless changes in different sectors of society. Among the various problems derived from this situation are the negative effects on the economy, since the condition in which the different economic agents find themselves is not favorable. Companies in all countries have been suffering the consequences within their life cycle, some of them having to close permanently and others looking for strategies not to die, or simply trying to survive. In Mexico, certain organizations analyze the damage that has affected the national economy, however, the information found in the different documents shows generalized data, and these effects cannot be identified locally. As a consequence, the objective of this study was to analyze the Micro and Small Enterprises (MSEs) in Atlacomulco, Mexico. For which, an instrument was developed with the indicators of the survey on the Economic Impact Generated by COVID-19 in Companies (ECOVID-IE) (INEGI, 2020). The study was made up of a sample of 40 MSEs from the study area, the main results show that the MSEs considered have been strongly affected.