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BackgroundAlthough obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength, and quality) and cardiovascular diseases in T2DM remain poorly investigated.MethodsWe enrolled 183 Japanese T2DM inpatients (126 men, 57 women; mean age 64.7 ± 12.6 years, ± SD). The estimated-visceral fat area (eVFA) and skeletal muscle mass were measured by each device using bioelectrical impedance analysis method. We also measured grip strength by dynamometer and motor nerve conduction velocity (MCV). We analyzed the difference in skeletal muscle indices between T2DM patients with and without visceral fat accumulation, and examined the impact of skeletal muscle indices on cardiovascular diseases in patients with visceral fat accumulation.ResultsThe prevalence of sarcopenia defined by the Consensus of Asian Working Group for Sarcopenia and low skeletal muscle mass were both lower in the visceral fat accumulation (+) group than in (−) group. However, the prevalence of weak hand grip strength was similar in the visceral fat accumulation (−) and (+) groups, indicating that considerable patients with visceral fat accumulation had weak grip strength in spite of fair skeletal muscle mass. Muscle quality [grip strength (kg)/arm muscle mass (kg)] was significantly lower in patients with visceral fat accumulation. Multiple regression analysis identified eVFA, MCV and sex as significant and independent determinants of muscle quality. In visceral fat accumulation (+) group, the patients with low muscle quality had longer duration of diabetes, lower eGFR, higher serum adiponectin, lower MCV and higher prevalence of cardiovascular diseases, compared to the patients with high muscle quality. Finally, sex- and age-adjusted models showed significant association between low muscle quality and cardiovascular diseases in all subjects (odds ratio 2.28, p = 0.012), especially in patients with visceral fat accumulation (odds ratio 2.72, p = 0.018).ConclusionsT2DM patients with visceral fat accumulation had low muscle quality, and patients with low muscle quality were more affected with cardiovascular diseases.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0755-3) contains supplementary material, which is available to authorized users.

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(α-Ethoxyvinyl)tributyltin acts as a masked acetylating agent in the palladium catalyzed reaction with various organic halides, such as aryl bromides, vinyl bromides, benzyl chloride, and allyl chloride, giving, after hydrolysis of the resulting reaction mixture, good yields of the corresponding ketone product.

It is important to ensure the security of biometric authentication information, because its leakage causes serious risks, such as replay attacks using the stolen biometric data, and also because it is almost impossible to replace raw biometric information. In this paper, we propose a secure biometric authentication scheme that protects such information by employing an optical data ciphering technique based on compressed sensing. The proposed scheme is based on two-factor authentication, the biometric information being supplemented by secret information that is used as a random seed for a cipher key. In this scheme, a biometric image is optically encrypted at the time of image capture, and a pair of restored biometric images for enrollment and verification are verified in the authentication server. If any of the biometric information is exposed to risk, it can be reenrolled by changing the secret information. Through numerical experiments, we confirm that finger vein images can be restored from the compressed sensing measurement data. We also present results that verify the accuracy of the scheme.