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18A small and wireless device that can capture the temporal pattern of perspiration by a novel 19 structure of water vapor collection combined with reusable desiccant has been developed. The 20 novel device consists of a small cylindrical case with a temperature/relative humidity sensor, 21 battery-driven data logger, and silica gel (desiccant). Water vapor of perspiration was detected 22by the change in relative humidity and then adsorbed by silica gel, allowing continuous 23 recording of perspiration within a closed and wireless chamber, which has not been previously 24 achieved. By comparative experiments using the commercially-available perspiration 25 monitoring device, the developed device could measure perspiration as efficiently as the 26 conventional one, with a normalized cross coefficient of 0.738 with 6 s delay and the interclass 27 correlation coefficient [ICC(2, 1)] of 0.84. These results imply a good agreement between the 28 conventional and developed devices, and thus suggest the applicability of the developed device 29 for perspiration monitoring. 30 31

Sweating, the intermittent secretion of uid from the sweat glands, is an indispensable mechanism for the regulation of body temperature. The methods used to measure the sweat rate include an iodine starch test, a weight assay, and an ion electric conductivity method. The ventilation capsule method is another method for quanti cation of sweat rate. However, this method has a problem in that the subject s physical activity is restricted by the rmly attached measurement probes. SNT-200, a wearable sweat meter developed by Rousette Strategy Inc., is already commercially available. This sweat meter contains silica gel that serves as an absorbent for sudoriferous steam and uses a temperature-humidity sensor to detect humidity changes in the device caused by sweating. However, the accuracy of the measurement has not yet been suf ciently investigated. This study was designed to provide evidence to validate the underlying measurement principle and accuracy of the device. We simulated various sweating conditions and performed simulated sweating measurements using SNT-200. In the rst experiment, continuous sweating over a wide body surface was simulated. The calculated absorbed steam volume was 1.84 times greater than the real transpiration rate. In the second experiment, sweating was simulated in the form of water drops, and the sweat meter absorbed the generated steam. In the second experiment, the data obtained using SNT-200 was in good accord with the volume dispensed by a micropipette. These experiments provided convincing evidence that the total area of four steam holes (A1, in the equation for calculating the sweat rate) required correction. We therefore modeled the effective absorption area of the sweat meter as one circle encompassing the four holes (8 mm in diameter; 52 mm 2) instead of a summation of the areas of four steam holes. De ning the effective absorption area by this method modi ed the value calculated in the rst experiment, which agreed with the transpiration rate. In addition, the modi ed moisture absorption volume in the sweat meter converged within ± 20% error of the actual measurement, except at 30 C.

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